Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 762325..762975 Replicon chromosome
Accession NZ_CP103833
Organism Actinobacillus arthritidis strain CCUG24862

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NYR89_RS03635 Protein ID WP_279446381.1
Coordinates 762325..762714 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B0BNU4
Locus tag NYR89_RS03640 Protein ID WP_005604117.1
Coordinates 762715..762975 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR89_RS03620 (NYR89_03620) 758094..759290 + 1197 WP_279446378.1 aspartate/tyrosine/aromatic aminotransferase -
NYR89_RS03625 (NYR89_03625) 759469..760755 - 1287 WP_279446380.1 Xaa-Pro aminopeptidase -
NYR89_RS03630 (NYR89_03630) 760964..762188 - 1225 Protein_707 ATP-binding protein -
NYR89_RS03635 (NYR89_03635) 762325..762714 - 390 WP_279446381.1 type II toxin-antitoxin system VapC family toxin Toxin
NYR89_RS03640 (NYR89_03640) 762715..762975 - 261 WP_005604117.1 hypothetical protein Antitoxin
NYR89_RS03645 (NYR89_03645) 763109..765131 - 2023 Protein_710 excinuclease ABC subunit UvrB -
NYR89_RS03650 (NYR89_03650) 765308..766120 + 813 WP_279446383.1 iron uptake system protein EfeO -
NYR89_RS03655 (NYR89_03655) 766135..767327 + 1193 Protein_712 iron uptake transporter deferrochelatase/peroxidase subunit -
NYR89_RS03660 (NYR89_03660) 767340..767957 + 618 WP_279446384.1 Fe2+/Pb2+ permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14819.16 Da        Isoelectric Point: 5.1421

>T256777 WP_279446381.1 NZ_CP103833:c762714-762325 [Actinobacillus arthritidis]
MYMLDTNTVSYFFRQEPTVVKKLQQLNPELICISSVTVAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQS
RAEMEREGKIMGVQDQMIGAHALATECVLVSSDKAFQLIPNLVLENWWK

Download         Length: 390 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10289.63 Da        Isoelectric Point: 5.1867

>AT256777 WP_005604117.1 NZ_CP103833:c762975-762715 [Actinobacillus arthritidis]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N030

References