Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 82274..82983 Replicon chromosome
Accession NZ_CP103833
Organism Actinobacillus arthritidis strain CCUG24862

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NYR89_RS00415 Protein ID WP_279445875.1
Coordinates 82561..82983 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NYR89_RS00410 Protein ID WP_279445874.1
Coordinates 82274..82561 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR89_RS00395 (NYR89_00395) 77410..78591 + 1182 WP_279445871.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
NYR89_RS00400 (NYR89_00400) 78645..79193 + 549 WP_279445872.1 type IV pilus biogenesis/stability protein PilW -
NYR89_RS00405 (NYR89_00405) 79269..81608 + 2340 WP_279445873.1 Tex family protein -
NYR89_RS00410 (NYR89_00410) 82274..82561 + 288 WP_279445874.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NYR89_RS00415 (NYR89_00415) 82561..82983 + 423 WP_279445875.1 type II toxin-antitoxin system VapC family toxin Toxin
NYR89_RS00420 (NYR89_00420) 83493..84773 - 1281 WP_279446679.1 NAD(P)/FAD-dependent oxidoreductase -
NYR89_RS00425 (NYR89_00425) 84883..85401 - 519 WP_279445876.1 SprT family zinc-dependent metalloprotease -
NYR89_RS00430 (NYR89_00430) 85402..86171 - 770 Protein_78 ribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16264.13 Da        Isoelectric Point: 9.3983

>T256776 WP_279445875.1 NZ_CP103833:82561-82983 [Actinobacillus arthritidis]
MYLLDTNIVSELRKMESGKVDANVVKWFQQVNLTDAYLSVITLFEIKLGILQLKRKDIQQAKLLQSWFEQKLLPNFENRI
LPLDTKVMMTCAEFHIPDKKPLNDSYIAATAKAHRFKIVTRNVKDFKGCGVEVLNPFIEY

Download         Length: 423 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10651.94 Da        Isoelectric Point: 5.0806

>AT256776 WP_279445874.1 NZ_CP103833:82274-82561 [Actinobacillus arthritidis]
MAVISSKEFNQRASAVLKIAETEPVYITKWGKVVSVLASYAHYQAQTKSQSLAEAFSSTASTATLSEEAEQQFEQTLQQV
RQQIKIRVPDLSEWE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References