Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2322940..2323582 Replicon chromosome
Accession NZ_CP103831
Organism Actinobacillus equuli subsp. haemolyticus strain 1812

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR87_RS10830 Protein ID WP_005621659.1
Coordinates 2322940..2323311 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR87_RS10835 Protein ID WP_039198813.1
Coordinates 2323292..2323582 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR87_RS10815 (NYR87_10810) 2319447..2320301 + 855 WP_279437193.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR87_RS10820 (NYR87_10815) 2320345..2320914 - 570 WP_039198809.1 elongation factor P hydroxylase -
NYR87_RS10825 (NYR87_10820) 2320974..2322722 - 1749 WP_279481014.1 protein-disulfide reductase DsbD -
NYR87_RS10830 (NYR87_10825) 2322940..2323311 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR87_RS10835 (NYR87_10830) 2323292..2323582 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR87_RS10840 (NYR87_10835) 2323650..2324612 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR87_RS10845 (NYR87_10840) 2324685..2325182 + 498 WP_279481016.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR87_RS10850 (NYR87_10845) 2325406..2326140 + 735 WP_279438545.1 arginine ABC transporter ATP-binding protein ArtP -
NYR87_RS10855 (NYR87_10850) 2326161..2326880 + 720 WP_279481020.1 transporter substrate-binding domain-containing protein -
NYR87_RS10860 (NYR87_10855) 2326886..2327557 + 672 WP_279481023.1 arginine ABC transporter permease ArtQ -
NYR87_RS10865 (NYR87_10860) 2327557..2328240 + 684 WP_279443240.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256771 WP_005621659.1 NZ_CP103831:2322940-2323311 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256771 WP_039198813.1 NZ_CP103831:2323292-2323582 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References