Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 501822..503380 Replicon chromosome
Accession NZ_CP103831
Organism Actinobacillus equuli subsp. haemolyticus strain 1812

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYR87_RS02300 Protein ID WP_279481392.1
Coordinates 502058..503380 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NYR87_RS02295 Protein ID WP_279453733.1
Coordinates 501822..502064 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR87_RS02290 (NYR87_02290) 498089..501697 + 3609 WP_279481389.1 exodeoxyribonuclease V subunit beta -
NYR87_RS02295 (NYR87_02295) 501822..502064 + 243 WP_279453733.1 helix-turn-helix domain-containing protein Antitoxin
NYR87_RS02300 (NYR87_02300) 502058..503380 + 1323 WP_279481392.1 HipA domain-containing protein Toxin
NYR87_RS02305 (NYR87_02305) 503444..504694 - 1251 WP_039196443.1 NupC/NupG family nucleoside CNT transporter -
NYR87_RS02310 (NYR87_02310) 504727..505515 - 789 WP_279456544.1 radical SAM protein -
NYR87_RS02315 (NYR87_02315) 505517..507061 - 1545 WP_279442348.1 YjjI family glycine radical enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50378.11 Da        Isoelectric Point: 8.7799

>T256769 WP_279481392.1 NZ_CP103831:502058-503380 [Actinobacillus equuli subsp. haemolyticus]
MVKRLCVLMNGELVGFFERTMSGSHLFRYADEWFLSPNVRPISLSMPLRREVYQGKEVINFFDNLLPDHPQVRARIAARF
QADTQQPFELLAKIGRDATGAITLLEENTEIPNHKVIHATELNEKELHSLLLGYRQNAPLGMLDEAQDFRISIAGAQEKT
ALLWYNERWQLPHGLTPTTHIIKLPIGKIQTPKYQLDLSQSVDNELICLRLCAAFGLPSANVNLLEVGDVRALVVERFDR
KLHSSNQYFLRLPYEDFCQVFGLAPTQKYESDGGVGIRHIMDKLLYSNQISDRTQFMRTQFLFWVLGAIDGHAKNFSIAL
KSQSRYHLSPIYDVISAYPMLGGKGWHQSDLQLAMSLCSTQKGKKWSWQKIRPVHYLSTAKSVGFNQLEMKHIIEEISDT
ALRKLDFVADRLPININEQVRDQIFNGVKKQIGKIKLDNI

Download         Length: 1323 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9295.66 Da        Isoelectric Point: 8.6589

>AT256769 WP_279453733.1 NZ_CP103831:501822-502064 [Actinobacillus equuli subsp. haemolyticus]
MLINDPNSLAVYLRDIRKQQKQSQKMIAQRVGLRQATISTFESQPDKVTIETLFKIAHSLGLEIHLEEKHKNMFNGSDEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References