Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/NGN_SP-YefM
Location 67225..67934 Replicon chromosome
Accession NZ_CP103831
Organism Actinobacillus equuli subsp. haemolyticus strain 1812

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NYR87_RS00350 Protein ID WP_279481151.1
Coordinates 67512..67934 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NYR87_RS00345 Protein ID WP_279481148.1
Coordinates 67225..67512 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR87_RS00330 (NYR87_00330) 62756..63937 + 1182 WP_278225213.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
NYR87_RS00335 (NYR87_00335) 63991..64539 + 549 WP_279481145.1 type IV pilus biogenesis/stability protein PilW -
NYR87_RS00340 (NYR87_00340) 64615..66954 + 2340 WP_279481146.1 Tex family protein -
NYR87_RS00345 (NYR87_00345) 67225..67512 + 288 WP_279481148.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NYR87_RS00350 (NYR87_00350) 67512..67934 + 423 WP_279481151.1 type II toxin-antitoxin system VapC family toxin Toxin
NYR87_RS00355 (NYR87_00355) 68041..69321 - 1281 WP_279471384.1 NAD(P)/FAD-dependent oxidoreductase -
NYR87_RS00360 (NYR87_00360) 69433..69951 - 519 WP_278225217.1 SprT family zinc-dependent metalloprotease -
NYR87_RS00365 (NYR87_00365) 69952..70722 - 771 WP_279481152.1 ribonuclease -
NYR87_RS00370 (NYR87_00370) 70843..72699 - 1857 WP_279481154.1 signal peptide peptidase SppA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16131.92 Da        Isoelectric Point: 9.4570

>T256768 WP_279481151.1 NZ_CP103831:67512-67934 [Actinobacillus equuli subsp. haemolyticus]
MYLLDTNIVSELRKMESGKADVNVVKWFQQINLTDAYLSVITLFEIKLGILQLKRKDIQQAKLLQSWFEQKLLPNFENRI
LPLDSKVMMTCAEFHIPDKKPLNDSYIAATAKAHRFKIVSRNVKDFKGCGVEVLNPFAES

Download         Length: 423 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10668.99 Da        Isoelectric Point: 4.7947

>AT256768 WP_279481148.1 NZ_CP103831:67225-67512 [Actinobacillus equuli subsp. haemolyticus]
MAVISSKEFNQRASAVLKIAETEPVYITKWGKVVSVLASYAHYQAQTKSQSLAEAFSGTALTEILSEEAEQQFERTLQQV
RQQSKMSVPDLSEWE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References