Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2336614..2337256 Replicon chromosome
Accession NZ_CP103830
Organism Actinobacillus equuli subsp. equuli strain 2499

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR86_RS10750 Protein ID WP_005621659.1
Coordinates 2336614..2336985 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR86_RS10755 Protein ID WP_039198813.1
Coordinates 2336966..2337256 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR86_RS10735 (NYR86_10735) 2333123..2333977 + 855 WP_039198806.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR86_RS10740 (NYR86_10740) 2334021..2334590 - 570 WP_039198809.1 elongation factor P hydroxylase -
NYR86_RS10745 (NYR86_10745) 2334648..2336396 - 1749 WP_279623287.1 protein-disulfide reductase DsbD -
NYR86_RS10750 (NYR86_10750) 2336614..2336985 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR86_RS10755 (NYR86_10755) 2336966..2337256 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR86_RS10760 (NYR86_10760) 2337324..2338286 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR86_RS10765 (NYR86_10765) 2338359..2338856 + 498 WP_278226779.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR86_RS10770 (NYR86_10770) 2339081..2339815 + 735 WP_039198820.1 arginine ABC transporter ATP-binding protein ArtP -
NYR86_RS10775 (NYR86_10775) 2339835..2340554 + 720 WP_279443239.1 transporter substrate-binding domain-containing protein -
NYR86_RS10780 (NYR86_10780) 2340560..2341231 + 672 WP_039198825.1 arginine ABC transporter permease ArtQ -
NYR86_RS10785 (NYR86_10785) 2341231..2341914 + 684 WP_279623288.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256767 WP_005621659.1 NZ_CP103830:2336614-2336985 [Actinobacillus equuli subsp. equuli]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256767 WP_039198813.1 NZ_CP103830:2336966-2337256 [Actinobacillus equuli subsp. equuli]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References