Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2267650..2268292 Replicon chromosome
Accession NZ_CP103829
Organism Actinobacillus equuli subsp. haemolyticus strain 2863

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR66_RS10620 Protein ID WP_005621659.1
Coordinates 2267650..2268021 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR66_RS10625 Protein ID WP_039198813.1
Coordinates 2268002..2268292 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR66_RS10605 (NYR66_10610) 2264157..2265011 + 855 WP_275217246.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR66_RS10610 (NYR66_10615) 2265055..2265624 - 570 WP_115587467.1 elongation factor P hydroxylase -
NYR66_RS10615 (NYR66_10620) 2265684..2267432 - 1749 WP_279456036.1 protein-disulfide reductase DsbD -
NYR66_RS10620 (NYR66_10625) 2267650..2268021 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR66_RS10625 (NYR66_10630) 2268002..2268292 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR66_RS10630 (NYR66_10635) 2268360..2269322 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR66_RS10635 (NYR66_10640) 2269395..2269892 + 498 WP_039198817.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR66_RS10640 (NYR66_10645) 2270117..2270851 + 735 WP_039198820.1 arginine ABC transporter ATP-binding protein ArtP -
NYR66_RS10645 (NYR66_10650) 2270871..2271590 + 720 WP_279456037.1 transporter substrate-binding domain-containing protein -
NYR66_RS10650 (NYR66_10655) 2271596..2272267 + 672 WP_279456038.1 arginine ABC transporter permease ArtQ -
NYR66_RS10655 (NYR66_10660) 2272267..2272950 + 684 WP_279456039.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256765 WP_005621659.1 NZ_CP103829:2267650-2268021 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256765 WP_039198813.1 NZ_CP103829:2268002-2268292 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References