256762

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2286834..2287476 Replicon chromosome
Accession NZ_CP103828
Organism Actinobacillus equuli subsp. equuli strain 3009

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR83_RS10560 Protein ID WP_005621659.1
Coordinates 2286834..2287205 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR83_RS10565 Protein ID WP_039198813.1
Coordinates 2287186..2287476 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR83_RS10545 (NYR83_10545) 2283342..2284196 + 855 WP_039198806.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR83_RS10550 (NYR83_10550) 2284240..2284809 - 570 WP_039198809.1 elongation factor P hydroxylase -
NYR83_RS10555 (NYR83_10555) 2284868..2286616 - 1749 WP_279443238.1 protein-disulfide reductase DsbD -
NYR83_RS10560 (NYR83_10560) 2286834..2287205 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR83_RS10565 (NYR83_10565) 2287186..2287476 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR83_RS10570 (NYR83_10570) 2287544..2288506 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR83_RS10575 (NYR83_10575) 2288579..2289076 + 498 WP_039198817.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR83_RS10580 (NYR83_10580) 2289301..2290035 + 735 WP_039198820.1 arginine ABC transporter ATP-binding protein ArtP -
NYR83_RS10585 (NYR83_10585) 2290055..2290774 + 720 WP_279443239.1 transporter substrate-binding domain-containing protein -
NYR83_RS10590 (NYR83_10590) 2290780..2291451 + 672 WP_278226783.1 arginine ABC transporter permease ArtQ -
NYR83_RS10595 (NYR83_10595) 2291451..2292134 + 684 WP_279443240.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256762 WP_005621659.1 NZ_CP103828:2286834-2287205 [Actinobacillus equuli subsp. equuli]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256762 WP_039198813.1 NZ_CP103828:2287186-2287476 [Actinobacillus equuli subsp. equuli]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References