Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2300724..2301366 Replicon chromosome
Accession NZ_CP103827
Organism Actinobacillus equuli subsp. haemolyticus strain 3090

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR82_RS10840 Protein ID WP_005621659.1
Coordinates 2300724..2301095 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR82_RS10845 Protein ID WP_039198813.1
Coordinates 2301076..2301366 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR82_RS10825 (NYR82_10830) 2297231..2298085 + 855 WP_279442033.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR82_RS10830 (NYR82_10835) 2298129..2298698 - 570 WP_039198809.1 elongation factor P hydroxylase -
NYR82_RS10835 (NYR82_10840) 2298758..2300506 - 1749 WP_279442034.1 protein-disulfide reductase DsbD -
NYR82_RS10840 (NYR82_10845) 2300724..2301095 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR82_RS10845 (NYR82_10850) 2301076..2301366 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR82_RS10850 (NYR82_10855) 2301434..2302396 - 963 WP_279442035.1 calcium/sodium antiporter -
NYR82_RS10855 (NYR82_10860) 2302469..2302966 + 498 WP_015674483.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR82_RS10860 (NYR82_10865) 2303189..2303923 + 735 WP_279442036.1 arginine ABC transporter ATP-binding protein ArtP -
NYR82_RS10865 (NYR82_10870) 2303944..2304663 + 720 WP_279442037.1 transporter substrate-binding domain-containing protein -
NYR82_RS10870 (NYR82_10875) 2304669..2305340 + 672 WP_015674486.1 arginine ABC transporter permease ArtQ -
NYR82_RS10875 (NYR82_10880) 2305340..2306023 + 684 WP_279442038.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256760 WP_005621659.1 NZ_CP103827:2300724-2301095 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256760 WP_039198813.1 NZ_CP103827:2301076-2301366 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References