Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 497401..498959 Replicon chromosome
Accession NZ_CP103827
Organism Actinobacillus equuli subsp. haemolyticus strain 3090

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYR82_RS02260 Protein ID WP_279442347.1
Coordinates 497637..498959 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NYR82_RS02255 Protein ID WP_279442346.1
Coordinates 497401..497643 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR82_RS02250 (NYR82_02255) 493667..497277 + 3611 Protein_435 exodeoxyribonuclease V subunit beta -
NYR82_RS02255 (NYR82_02260) 497401..497643 + 243 WP_279442346.1 helix-turn-helix domain-containing protein Antitoxin
NYR82_RS02260 (NYR82_02265) 497637..498959 + 1323 WP_279442347.1 HipA domain-containing protein Toxin
NYR82_RS02265 (NYR82_02270) 499023..500273 - 1251 WP_039196443.1 NupC/NupG family nucleoside CNT transporter -
NYR82_RS02270 (NYR82_02275) 500313..501101 - 789 WP_279442776.1 radical SAM protein -
NYR82_RS02275 (NYR82_02280) 501103..502647 - 1545 WP_279442348.1 YjjI family glycine radical enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50336.02 Da        Isoelectric Point: 8.5624

>T256756 WP_279442347.1 NZ_CP103827:497637-498959 [Actinobacillus equuli subsp. haemolyticus]
MVKRLCVLMNGELVGFFERTMSGSHLFRYADEWFLSPNVRPISLSMPLRREVYQGKEVINFFDNLLPDHPQVRARIAARF
QAETQQPFELLAKIGRDATGAITLLEENTEIPNHKVIHATELNENELHSLLLGYQQNAPLGMLDEAQDFRISIAGAQEKT
ALLWYNERWQLPHGLTPTTHIIKLPIGKIQTPKYQLDLSQSVDNELICLRLCAAFGLPTANVNLLEVGDVRALVVERFDR
KLHSSNKYFLRLPYEDFCQVFGLAPTQKYESDGGIGIRHIMDKLLYSSHTSDRAQFMKTQFLFWVLGAIDGHAKNFSIAL
KSQSRYHLSPIYDVISAYPMSGGKGWHQSDLQLAMSLCSTQKGKKWSWQKIRPVHYLSTAKSVGFNQLEMKHIIEEISDT
ALKKLDFVADRLPININEQVRDQIFNGVKKQIDKIKLDRI

Download         Length: 1323 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9409.81 Da        Isoelectric Point: 8.6782

>AT256756 WP_279442346.1 NZ_CP103827:497401-497643 [Actinobacillus equuli subsp. haemolyticus]
MLINDPNSLAVYLRDIRKQQKQSQKMIAQRVGLRQATISTFETQPDKVTIETLFKIVHSLGLEIHLEEKHTNMFNRSDEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References