Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2301051..2301693 Replicon chromosome
Accession NZ_CP103826
Organism Actinobacillus equuli subsp. haemolyticus strain 3113

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR81_RS10865 Protein ID WP_005621659.1
Coordinates 2301051..2301422 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR81_RS10870 Protein ID WP_039198813.1
Coordinates 2301403..2301693 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR81_RS10850 (NYR81_10850) 2297557..2298411 + 855 WP_279442033.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR81_RS10855 (NYR81_10855) 2298455..2299024 - 570 WP_039198809.1 elongation factor P hydroxylase -
NYR81_RS10860 (NYR81_10860) 2299084..2300833 - 1750 Protein_2084 protein-disulfide reductase DsbD -
NYR81_RS10865 (NYR81_10865) 2301051..2301422 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR81_RS10870 (NYR81_10870) 2301403..2301693 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR81_RS10875 (NYR81_10875) 2301761..2302723 - 963 WP_279442035.1 calcium/sodium antiporter -
NYR81_RS10880 (NYR81_10880) 2302796..2303293 + 498 WP_015674483.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR81_RS10885 (NYR81_10885) 2303516..2304250 + 735 WP_279442036.1 arginine ABC transporter ATP-binding protein ArtP -
NYR81_RS10890 (NYR81_10890) 2304271..2304990 + 720 WP_279442037.1 transporter substrate-binding domain-containing protein -
NYR81_RS10895 (NYR81_10895) 2304996..2305667 + 672 WP_015674486.1 arginine ABC transporter permease ArtQ -
NYR81_RS10900 (NYR81_10900) 2305667..2306350 + 684 WP_279442038.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256755 WP_005621659.1 NZ_CP103826:2301051-2301422 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256755 WP_039198813.1 NZ_CP103826:2301403-2301693 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References