Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1246586..1248144 Replicon chromosome
Accession NZ_CP103826
Organism Actinobacillus equuli subsp. haemolyticus strain 3113

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYR81_RS05730 Protein ID WP_279479059.1
Coordinates 1246586..1247908 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NYR81_RS05735 Protein ID WP_279479060.1
Coordinates 1247902..1248144 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR81_RS05715 (NYR81_05715) 1242898..1244442 + 1545 WP_279442348.1 YjjI family glycine radical enzyme -
NYR81_RS05720 (NYR81_05720) 1244444..1245232 + 789 WP_279442776.1 radical SAM protein -
NYR81_RS05725 (NYR81_05725) 1245272..1246522 + 1251 WP_039196443.1 NupC/NupG family nucleoside CNT transporter -
NYR81_RS05730 (NYR81_05730) 1246586..1247908 - 1323 WP_279479059.1 HipA domain-containing protein Toxin
NYR81_RS05735 (NYR81_05735) 1247902..1248144 - 243 WP_279479060.1 helix-turn-helix domain-containing protein Antitoxin
NYR81_RS05740 (NYR81_05740) 1248268..1251878 - 3611 Protein_1115 exodeoxyribonuclease V subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50346.06 Da        Isoelectric Point: 8.5624

>T256752 WP_279479059.1 NZ_CP103826:c1247908-1246586 [Actinobacillus equuli subsp. haemolyticus]
MVKRLCVLMNGELVGFFERTMSGSHLFRYADEWFLSPNVRPISLSMPLRREVYQGKEVINFFDNLLPDHPQVRARIAARF
QAETQQPFELLAKIGRDATGAITLLEENTEIPNHKVIHATELNENELHSLLLGYQQNAPLGMLDEAQDFRISIAGAQEKT
ALLWYNERWQLPHGLTPTTHIIKLPIGKIQTPKYQLDLSQSVDNELICLRLCAAFGLPTANVNLLEVGDVRALVVERFDR
KLHSSNKYFLRLPYEDFCQVFGLAPTQKYESDGGIGIRHIMDKLLYSSHTSDRAQFMKTQFLFWVLGAIDGHAKNFSIAL
KSQSRYHLSPIYDVISAYPMPGGKGWHQSDLQLAMSLCSTQKGKKWSWQKIRPVHYLSTAKSVGFNQLEMKHIIEEISDT
ALKKLDFVADRLPININEQVRDQIFNGVKKQIDKIKLDRI

Download         Length: 1323 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.87 Da        Isoelectric Point: 9.8647

>AT256752 WP_279479060.1 NZ_CP103826:c1248144-1247902 [Actinobacillus equuli subsp. haemolyticus]
MLINDPNSLAVYLRDIRKQQKQSQKMIAQRVGLRQATISTFETRPDKVTIETLFKIVHSLGLEIHLEEKHTNMFNRSDEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References