Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2310263..2310905 Replicon chromosome
Accession NZ_CP103825
Organism Actinobacillus equuli subsp. haemolyticus strain 3282

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR80_RS10710 Protein ID WP_005621659.1
Coordinates 2310263..2310634 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR80_RS10715 Protein ID WP_039198813.1
Coordinates 2310615..2310905 (+) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR80_RS10695 (NYR80_10700) 2306770..2307624 + 855 WP_039198806.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR80_RS10700 (NYR80_10705) 2307668..2308237 - 570 WP_039198809.1 elongation factor P hydroxylase -
NYR80_RS10705 (NYR80_10710) 2308297..2310045 - 1749 WP_279438543.1 protein-disulfide reductase DsbD -
NYR80_RS10710 (NYR80_10715) 2310263..2310634 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR80_RS10715 (NYR80_10720) 2310615..2310905 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR80_RS10720 (NYR80_10725) 2310973..2311935 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR80_RS10725 (NYR80_10730) 2312008..2312505 + 498 WP_279438544.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR80_RS10730 (NYR80_10735) 2312730..2313464 + 735 WP_279438545.1 arginine ABC transporter ATP-binding protein ArtP -
NYR80_RS10735 (NYR80_10740) 2313485..2314204 + 720 WP_279438546.1 transporter substrate-binding domain-containing protein -
NYR80_RS10740 (NYR80_10745) 2314210..2314881 + 672 WP_015674486.1 arginine ABC transporter permease ArtQ -
NYR80_RS10745 (NYR80_10750) 2314881..2315564 + 684 WP_279438547.1 arginine ABC transporter permease ArtM -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(33-109)

Antitoxin

(34-85)


Sequences


Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256750 WP_005621659.1 NZ_CP103825:2310263-2310634 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp


Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256750 WP_039198813.1 NZ_CP103825:2310615-2310905 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46


Antitoxin

Source ID Structure

References