Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 1894491..1896148 | Replicon | chromosome |
| Accession | NZ_CP103825 | ||
| Organism | Actinobacillus equuli subsp. haemolyticus strain 3282 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | NYR80_RS08715 | Protein ID | WP_279438360.1 |
| Coordinates | 1894817..1896148 (-) | Length | 444 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A3N2X7 |
| Locus tag | NYR80_RS08710 | Protein ID | WP_005613259.1 |
| Coordinates | 1894491..1894820 (-) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NYR80_RS08695 (NYR80_08700) | 1889554..1890834 | + | 1281 | WP_278226526.1 | threonine synthase | - |
| NYR80_RS08700 (NYR80_08705) | 1891264..1892529 | + | 1266 | WP_279438358.1 | pentapeptide repeat-containing protein | - |
| NYR80_RS08705 (NYR80_08710) | 1892827..1894152 | - | 1326 | WP_279438359.1 | MFS transporter family glucose-6-phosphate receptor UhpC | - |
| NYR80_RS08710 (NYR80_08715) | 1894491..1894820 | - | 330 | WP_005613259.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NYR80_RS08715 (NYR80_08720) | 1894817..1896148 | - | 1332 | WP_279438360.1 | HipA domain-containing protein | Toxin |
| NYR80_RS08720 (NYR80_08725) | 1896550..1897578 | + | 1029 | WP_279438361.1 | Abi family protein | - |
| NYR80_RS08725 (NYR80_08730) | 1897807..1898196 | - | 390 | WP_279438362.1 | hypothetical protein | - |
| NYR80_RS08730 (NYR80_08735) | 1898199..1898708 | - | 510 | WP_279438363.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 444 a.a. Molecular weight: 51183.05 Da Isoelectric Point: 5.2284
>T256747 WP_279438360.1 NZ_CP103825:c1896148-1894817 [Actinobacillus equuli subsp. haemolyticus]
MSDISVKNKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANARSISINYPVNVFIDHVDKLMTTLADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAIPEIQSERYFPLNVVQNRQSDFLEYANQTGAIVGG
ATGAGGEAPKLLLKRQDKQVWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEG
QRYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYGGNLDHEQTIRNLLNVISASQFSNDFDNRHFVIEWVKRDLLNIAF
GNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGIIRTTTWAKNGDNSQEFAGEYRFDKIADSLSDLIEPDILLRELR
MLATQLVDLKSRLTKRGVPKSILDFPAIGFDYLPEKLQRWGLV
MSDISVKNKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANARSISINYPVNVFIDHVDKLMTTLADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAIPEIQSERYFPLNVVQNRQSDFLEYANQTGAIVGG
ATGAGGEAPKLLLKRQDKQVWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEG
QRYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYGGNLDHEQTIRNLLNVISASQFSNDFDNRHFVIEWVKRDLLNIAF
GNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGIIRTTTWAKNGDNSQEFAGEYRFDKIADSLSDLIEPDILLRELR
MLATQLVDLKSRLTKRGVPKSILDFPAIGFDYLPEKLQRWGLV
Download Length: 1332 bp
Antitoxin
Download Length: 110 a.a. Molecular weight: 12320.45 Da Isoelectric Point: 10.8292
>AT256747 WP_005613259.1 NZ_CP103825:c1894820-1894491 [Actinobacillus equuli subsp. haemolyticus]
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK
Download Length: 330 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|