Detailed information of TA system TA256744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/couple_hipB(antitoxin)
• Location: 475753..477212
• Replicon: chromosome
• Accession: NZ_CP103824
• Organism: Actinobacillus equuli subsp. haemolyticus strain 3524

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: NYR79_RS02280
• Protein ID: WP_279455174.1
• Coordinates: 476079..477212 (-)
• Length: 378 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: NYR79_RS02275
• Protein ID: WP_279455173.1
• Coordinates: 475753..476082 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NYR79_RS02265 (NYR79_02265)	472594..473926	-	1333	Protein_425	IS3 family transposase	-
NYR79_RS02270 (NYR79_02270)	474080..475405	-	1326	WP_275218491.1	MFS transporter family glucose-6-phosphate receptor UhpC	-
NYR79_RS02275 (NYR79_02275)	475753..476082	-	330	WP_279455173.1	helix-turn-helix transcriptional regulator	Antitoxin
NYR79_RS02280 (NYR79_02280)	476079..477212	-	1134	WP_279455174.1	HipA domain-containing protein	Toxin
NYR79_RS02285 (NYR79_02285)	477477..479183	-	1707	WP_279455175.1	AIPR family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	463816..479183	15367

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (164-296)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-94)

Sequences

Toxin

Protein

• Length: 378 a.a.
• Molecular weight: 43370.34 Da
• Isoelectric Point: 4.9547

>T256744 WP_279455174.1 NZ_CP103824:c477212-476079 [Actinobacillus equuli subsp. haemolyticus]
MSDISVKNKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANARSISINYPVNVFIDHVDKLMTTLADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAVPEIQSERYFPLNVVQNRQSDFLEYANQTGAIVGG
ATGAGGEAPKLLLKRQDKQVWIDNLQLGLDCDTTYLVKYPRGNYSALDCDILRAEYHYYHELCALGFSTIDTDLMKLEEG
ERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQRYGGNLDHEQTIRNLLNVISASQFSNNFDNPQEFAGEYRFDKIADGL
SDLIEPDILLRELRMLATQLVDLKSRLTKRGVPKSILDFPAIGFDYLPDKLQRWGLV

Nucleotide

• Length: 1134 bp

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12426.64 Da
• Isoelectric Point: 10.8518

>AT256744 WP_279455173.1 NZ_CP103824:c476082-475753 [Actinobacillus equuli subsp. haemolyticus]
MTIQHKNSSPTRPKMNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQYYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Nucleotide

• Length: 330 bp