256742

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 89690..90332 Replicon chromosome
Accession NZ_CP103824
Organism Actinobacillus equuli subsp. haemolyticus strain 3524

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR79_RS00375 Protein ID WP_005621659.1
Coordinates 89961..90332 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR79_RS00370 Protein ID WP_039198813.1
Coordinates 89690..89980 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR79_RS00340 (NYR79_00340) 85032..85715 - 684 WP_279455017.1 arginine ABC transporter permease ArtM -
NYR79_RS00345 (NYR79_00345) 85715..86386 - 672 WP_015674486.1 arginine ABC transporter permease ArtQ -
NYR79_RS00350 (NYR79_00350) 86392..87111 - 720 WP_275217249.1 transporter substrate-binding domain-containing protein -
NYR79_RS00355 (NYR79_00355) 87132..87866 - 735 WP_279438545.1 arginine ABC transporter ATP-binding protein ArtP -
NYR79_RS00360 (NYR79_00360) 88090..88587 - 498 WP_278226779.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR79_RS00365 (NYR79_00365) 88660..89622 + 963 WP_039198815.1 calcium/sodium antiporter -
NYR79_RS00370 (NYR79_00370) 89690..89980 - 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR79_RS00375 (NYR79_00375) 89961..90332 - 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR79_RS00380 (NYR79_00380) 90550..92298 + 1749 WP_279455019.1 protein-disulfide reductase DsbD -
NYR79_RS00385 (NYR79_00385) 92357..92926 + 570 WP_279455527.1 elongation factor P hydroxylase -
NYR79_RS00390 (NYR79_00390) 92970..93824 - 855 WP_039198806.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256742 WP_005621659.1 NZ_CP103824:c90332-89961 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256742 WP_039198813.1 NZ_CP103824:c89980-89690 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References