Detailed information of TA system TA025674

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 4097871..4098412
• Replicon: chromosome
• Accession: NC_016109
• Organism: Kitasatospora setae KM-6054

Toxin (Protein)

• Gene name: relE
• Uniprot ID: E4NE46
• Locus tag: KSE_RS18125
• Protein ID: WP_014136783.1
• Coordinates: 4098146..4098412 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E4NE45
• Locus tag: KSE_RS18120
• Protein ID: WP_014136782.1
• Coordinates: 4097871..4098149 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSE_RS18110	4095513..4095974	+	462	WP_014136779.1	hypothetical protein	-
KSE_RS18115	4096720..4097763	+	1044	WP_081539469.1	DUF4365 domain-containing protein	-
KSE_RS18120	4097871..4098149	+	279	WP_014136782.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KSE_RS18125	4098146..4098412	+	267	WP_014136783.1	Txe/YoeB family addiction module toxin	Toxin
KSE_RS18130	4099280..4100587	-	1308	WP_014136784.1	aspartate--tRNA(Asn) ligase	-
KSE_RS18135	4101093..4102394	+	1302	WP_014136785.1	hypothetical protein	-
KSE_RS18140	4102629..4102850	-	222	WP_014136786.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10415.81 Da
• Isoelectric Point: 7.3215

>T25674 WP_014136783.1 NC_016109:4098146-4098412 [Kitasatospora setae KM-6054]
VKVQFTEHGWADYLSWQADDRRLLKRINLLIDDIRRNGNEGIGKPEPLRHELAGAWSRRIDQEHRLIYVLDEQADTLCVI
ACRYHYGK

Nucleotide

• Length: 267 bp

>T25674 NC_016109:4098146-4098412 [Kitasatospora setae KM-6054]
GTGAAAGTCCAGTTCACCGAACACGGCTGGGCCGACTACCTGTCCTGGCAGGCGGACGACCGTCGGCTCCTCAAGCGCAT
CAACCTGTTGATCGACGACATCCGCCGAAACGGCAACGAGGGCATCGGCAAGCCCGAACCCCTGCGGCACGAGCTCGCCG
GCGCCTGGTCTCGCAGGATCGACCAGGAACACCGCTTGATCTACGTCCTGGACGAGCAGGCCGACACCTTGTGCGTCATC
GCCTGCCGCTACCACTACGGCAAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10153.30 Da
• Isoelectric Point: 4.3633

>AT25674 WP_014136782.1 NC_016109:4097871-4098149 [Kitasatospora setae KM-6054]
MKTMSATELRGNLAAALDAVESDAEELVITRAGHEPLVVVSLAEYASLRETDYLLRSPANAEHLRRSLQEYREGRAATRE
LIDPEDLAEQSA

Nucleotide

• Length: 279 bp

>AT25674 NC_016109:4097871-4098149 [Kitasatospora setae KM-6054]
ATGAAGACGATGAGTGCTACCGAGCTCCGCGGCAACCTTGCCGCCGCGCTGGACGCCGTCGAGAGTGACGCCGAAGAGCT
CGTCATCACACGTGCTGGCCACGAGCCGCTGGTCGTCGTCTCGCTGGCCGAGTACGCCTCGCTCCGTGAGACCGATTACC
TTCTGCGGTCCCCGGCCAACGCCGAACACCTTCGCCGCTCCCTGCAGGAGTACCGGGAAGGCCGTGCGGCGACCCGCGAA
CTGATCGACCCCGAGGACCTCGCCGAGCAGAGCGCGTGA

Structures

Toxin

• AlphaFold DB: E4NE46