256737

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2273423..2274065 Replicon chromosome
Accession NZ_CP103820
Organism Actinobacillus equuli subsp. haemolyticus strain 3820

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR75_RS10665 Protein ID WP_005621659.1
Coordinates 2273423..2273794 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR75_RS10670 Protein ID WP_039198813.1
Coordinates 2273775..2274065 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR75_RS10650 (NYR75_10655) 2269931..2270785 + 855 WP_279471818.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR75_RS10655 (NYR75_10660) 2270829..2271398 - 570 WP_279437970.1 elongation factor P hydroxylase -
NYR75_RS10660 (NYR75_10665) 2271457..2273205 - 1749 WP_279471819.1 protein-disulfide reductase DsbD -
NYR75_RS10665 (NYR75_10670) 2273423..2273794 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR75_RS10670 (NYR75_10675) 2273775..2274065 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR75_RS10675 (NYR75_10680) 2274133..2275095 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR75_RS10680 (NYR75_10685) 2275168..2275665 + 498 WP_279471820.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR75_RS10685 (NYR75_10690) 2275889..2276623 + 735 WP_279471821.1 arginine ABC transporter ATP-binding protein ArtP -
NYR75_RS10690 (NYR75_10695) 2276644..2277363 + 720 WP_279471822.1 transporter substrate-binding domain-containing protein -
NYR75_RS10695 (NYR75_10700) 2277369..2278040 + 672 WP_015674486.1 arginine ABC transporter permease ArtQ -
NYR75_RS10700 (NYR75_10705) 2278040..2278723 + 684 WP_279443240.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256737 WP_005621659.1 NZ_CP103820:2273423-2273794 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256737 WP_039198813.1 NZ_CP103820:2273775-2274065 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References