Detailed information of TA system TA256734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1666294..1667597
• Replicon: chromosome
• Accession: NZ_CP103819
• Organism: Actinobacillus equuli subsp. haemolyticus strain 3873

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: NYR74_RS07760
• Protein ID: WP_279454196.1
• Coordinates: 1666294..1667271 (+)
• Length: 326 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: NYR74_RS07765
• Protein ID: WP_279453265.1
• Coordinates: 1667268..1667597 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NYR74_RS07740 (NYR74_07740)	1663704..1664345	+	642	WP_005599134.1	DUF6037 family protein	-
NYR74_RS07745 (NYR74_07745)	1664500..1665207	-	708	WP_279453268.1	Abi family protein	-
NYR74_RS07750 (NYR74_07750)	1665132..1665536	-	405	WP_279453267.1	Abi family protein	-
NYR74_RS07755 (NYR74_07755)	1665939..1666334	+	396	WP_279454195.1	hypothetical protein	-
NYR74_RS07760 (NYR74_07760)	1666294..1667271	+	978	WP_279454196.1	HipA domain-containing protein	Toxin
NYR74_RS07765 (NYR74_07765)	1667268..1667597	+	330	WP_279453265.1	helix-turn-helix domain-containing protein	Antitoxin
NYR74_RS07770 (NYR74_07770)	1667936..1669261	+	1326	WP_279453264.1	MFS transporter family glucose-6-phosphate receptor UhpC	-
NYR74_RS07775 (NYR74_07775)	1669389..1670669	-	1281	WP_279453263.1	threonine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (46-261)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-94)

Sequences

Toxin

Protein

• Length: 326 a.a.
• Molecular weight: 37828.83 Da
• Isoelectric Point: 5.0344

>T256734 WP_279454196.1 NZ_CP103819:1666294-1667271 [Actinobacillus equuli subsp. haemolyticus]
MSELKRLYQEIQSERYFPLNVVQNRQSDFLEYANQTGAIVGGATGAGGEAPKLLLKRQDKQVWIDNLQLGLDCDTAYLVK
YPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEGERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYSGN
LDHEQTIRNLLNVISASQFSNDFDNRYFVIEWVKRDLLNIAFGNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGII
RTTTWAKNGDNPQEFAGEYRFDKIADGLSDLIEPDILLRELRMLATQLVDLKSRLTKRGVPKSILDFPAIGFDYLPEKLQ
RWGLV

Nucleotide

• Length: 978 bp

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12378.55 Da
• Isoelectric Point: 10.8292

>AT256734 WP_279453265.1 NZ_CP103819:1667268-1667597 [Actinobacillus equuli subsp. haemolyticus]
MTIQHKNSSPTRPKMNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Nucleotide

• Length: 330 bp