Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 1270409..1271051 Replicon chromosome
Accession NZ_CP103819
Organism Actinobacillus equuli subsp. haemolyticus strain 3873

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR74_RS05780 Protein ID WP_005621659.1
Coordinates 1270680..1271051 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR74_RS05775 Protein ID WP_039198813.1
Coordinates 1270409..1270699 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR74_RS05745 (NYR74_05745) 1265773..1266456 - 684 WP_279453445.1 arginine ABC transporter permease ArtM -
NYR74_RS05750 (NYR74_05750) 1266456..1267127 - 672 WP_275217250.1 arginine ABC transporter permease ArtQ -
NYR74_RS05755 (NYR74_05755) 1267133..1267852 - 720 WP_279453444.1 transporter substrate-binding domain-containing protein -
NYR74_RS05760 (NYR74_05760) 1267873..1268607 - 735 WP_279438545.1 arginine ABC transporter ATP-binding protein ArtP -
NYR74_RS05765 (NYR74_05765) 1268808..1269306 - 499 Protein_1127 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR74_RS05770 (NYR74_05770) 1269379..1270341 + 963 WP_039198815.1 calcium/sodium antiporter -
NYR74_RS05775 (NYR74_05775) 1270409..1270699 - 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR74_RS05780 (NYR74_05780) 1270680..1271051 - 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR74_RS05785 (NYR74_05785) 1271269..1273020 + 1752 WP_279453442.1 protein-disulfide reductase DsbD -
NYR74_RS05790 (NYR74_05790) 1273079..1273648 + 570 WP_279441422.1 elongation factor P hydroxylase -
NYR74_RS05795 (NYR74_05795) 1273692..1274546 - 855 WP_039198806.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256731 WP_005621659.1 NZ_CP103819:c1271051-1270680 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256731 WP_039198813.1 NZ_CP103819:c1270699-1270409 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References