Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 687667..689225 Replicon chromosome
Accession NZ_CP103819
Organism Actinobacillus equuli subsp. haemolyticus strain 3873

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYR74_RS03150 Protein ID WP_279453734.1
Coordinates 687667..688989 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NYR74_RS03155 Protein ID WP_279453733.1
Coordinates 688983..689225 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR74_RS03135 (NYR74_03135) 683979..685523 + 1545 WP_257175271.1 YjjI family glycine radical enzyme -
NYR74_RS03140 (NYR74_03140) 685525..686313 + 789 WP_279437947.1 radical SAM protein -
NYR74_RS03145 (NYR74_03145) 686353..687603 + 1251 WP_039196443.1 NupC/NupG family nucleoside CNT transporter -
NYR74_RS03150 (NYR74_03150) 687667..688989 - 1323 WP_279453734.1 HipA domain-containing protein Toxin
NYR74_RS03155 (NYR74_03155) 688983..689225 - 243 WP_279453733.1 helix-turn-helix domain-containing protein Antitoxin
NYR74_RS03160 (NYR74_03160) 689350..692958 - 3609 WP_279453732.1 exodeoxyribonuclease V subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50377.17 Da        Isoelectric Point: 9.1590

>T256730 WP_279453734.1 NZ_CP103819:c688989-687667 [Actinobacillus equuli subsp. haemolyticus]
MVKRLCVLMNGELVGFFERTMSGSHLFRYADEWFLSPNVRPISLSMPLRREVYQGKEVINFFDNLLPDHPQVRARIAARF
QADTQQPFELLAKIGRDATGAITLLEENTKIPNHKVIHATELNEKELHSLLLGYRQNAPLGMLDEAQDFRISIAGAQEKT
ALLWYNERWQLPHGLTPTTHIIKLPIGKIQTPKYQLDLSQSVDNELICLRLCAAFGLPSANVNLLEVGDVRALVVERFDR
KLHSSNQYFLRLPYEDFCQVFGLAPTQKYESDGGVGIRHIMDKLLYSNQISDRTQFMRTQFLFWVLGAIDGHAKNFSIAL
KSQSRYHLSPIYDVISAYPMLGGKGWHQSDLQLAMSLCSTQKGKKWSWQKIRPVHYLSTAKSVGFNQLEMKHIIEEISDT
ALRKLDFVADRLPININEQVRDQIFNGVKKQIGKIKLDNI

Download         Length: 1323 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9295.66 Da        Isoelectric Point: 8.6589

>AT256730 WP_279453733.1 NZ_CP103819:c689225-688983 [Actinobacillus equuli subsp. haemolyticus]
MLINDPNSLAVYLRDIRKQQKQSQKMIAQRVGLRQATISTFESQPDKVTIETLFKIAHSLGLEIHLEEKHKNMFNGSDEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References