Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2321134..2321776 Replicon chromosome
Accession NZ_CP103818
Organism Actinobacillus equuli subsp. haemolyticus strain 3874

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR73_RS10880 Protein ID WP_005621659.1
Coordinates 2321134..2321505 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR73_RS10885 Protein ID WP_039198813.1
Coordinates 2321486..2321776 (+) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR73_RS10865 (NYR73_10875) 2317639..2318493 + 855 WP_039198806.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR73_RS10870 (NYR73_10880) 2318537..2319106 - 570 WP_279441422.1 elongation factor P hydroxylase -
NYR73_RS10875 (NYR73_10885) 2319165..2320916 - 1752 WP_279453442.1 protein-disulfide reductase DsbD -
NYR73_RS10880 (NYR73_10890) 2321134..2321505 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR73_RS10885 (NYR73_10895) 2321486..2321776 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR73_RS10890 (NYR73_10900) 2321844..2322806 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR73_RS10895 (NYR73_10905) 2322879..2323376 + 498 WP_279453443.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR73_RS10900 (NYR73_10910) 2323577..2324311 + 735 WP_279438545.1 arginine ABC transporter ATP-binding protein ArtP -
NYR73_RS10905 (NYR73_10915) 2324332..2325051 + 720 WP_279453444.1 transporter substrate-binding domain-containing protein -
NYR73_RS10910 (NYR73_10920) 2325057..2325728 + 672 WP_275217250.1 arginine ABC transporter permease ArtQ -
NYR73_RS10915 (NYR73_10925) 2325728..2326411 + 684 WP_279453445.1 arginine ABC transporter permease ArtM -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(33-109)

Antitoxin

(34-85)


Sequences


Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256729 WP_005621659.1 NZ_CP103818:2321134-2321505 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp


Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256729 WP_039198813.1 NZ_CP103818:2321486-2321776 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46


Antitoxin

Source ID Structure

References