Detailed information of TA system TA256726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1924589..1926246
• Replicon: chromosome
• Accession: NZ_CP103818
• Organism: Actinobacillus equuli subsp. haemolyticus strain 3874

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: NYR73_RS08920
• Protein ID: WP_279453266.1
• Coordinates: 1924915..1926246 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: NYR73_RS08915
• Protein ID: WP_279453265.1
• Coordinates: 1924589..1924918 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NYR73_RS08905 (NYR73_08915)	1921517..1922797	+	1281	WP_279453263.1	threonine synthase	-
NYR73_RS08910 (NYR73_08920)	1922925..1924250	-	1326	WP_279453264.1	MFS transporter family glucose-6-phosphate receptor UhpC	-
NYR73_RS08915 (NYR73_08925)	1924589..1924918	-	330	WP_279453265.1	helix-turn-helix domain-containing protein	Antitoxin
NYR73_RS08920 (NYR73_08930)	1924915..1926246	-	1332	WP_279453266.1	HipA domain-containing protein	Toxin
NYR73_RS08925 (NYR73_08935)	1926649..1927053	+	405	WP_279453267.1	Abi family protein	-
NYR73_RS08930 (NYR73_08940)	1926978..1927685	+	708	WP_279453268.1	Abi family protein	-
NYR73_RS08935 (NYR73_08945)	1927840..1928481	-	642	WP_005599134.1	DUF6037 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (164-371)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-94)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51107.98 Da
• Isoelectric Point: 4.9570

>T256726 WP_279453266.1 NZ_CP103818:c1926246-1924915 [Actinobacillus equuli subsp. haemolyticus]
MSDISIKSKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANAGSISINYPVNVFIDHVDKLMTTLADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAIPEIQSERYFPLNVVQNRQSDFLEYANQTGAIVGG
ATGAGGEAPKLLLKRQDKQVWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEG
ERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYSGNLDHEQTIRNLLNVISASQFSNDFDNRYFVIEWVKRDLLNIAF
GNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGIIRTTTWAKNGDNPQEFAGEYRFDKIADGLSDLIEPDILLRELR
MLATQLVDLKSRLTKRGVPKSILDFPAIGFDYLPEKLQRWGLV

Nucleotide

• Length: 1332 bp

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12378.55 Da
• Isoelectric Point: 10.8292

>AT256726 WP_279453265.1 NZ_CP103818:c1924918-1924589 [Actinobacillus equuli subsp. haemolyticus]
MTIQHKNSSPTRPKMNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Nucleotide

• Length: 330 bp