Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 508491..510049 Replicon chromosome
Accession NZ_CP103818
Organism Actinobacillus equuli subsp. haemolyticus strain 3874

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYR73_RS02325 Protein ID WP_279453734.1
Coordinates 508727..510049 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NYR73_RS02320 Protein ID WP_279453733.1
Coordinates 508491..508733 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR73_RS02315 (NYR73_02315) 504758..508366 + 3609 WP_279453732.1 exodeoxyribonuclease V subunit beta -
NYR73_RS02320 (NYR73_02320) 508491..508733 + 243 WP_279453733.1 helix-turn-helix domain-containing protein Antitoxin
NYR73_RS02325 (NYR73_02325) 508727..510049 + 1323 WP_279453734.1 HipA domain-containing protein Toxin
NYR73_RS02330 (NYR73_02330) 510113..511363 - 1251 WP_039196443.1 NupC/NupG family nucleoside CNT transporter -
NYR73_RS02335 (NYR73_02335) 511403..512191 - 789 WP_279437947.1 radical SAM protein -
NYR73_RS02340 (NYR73_02340) 512193..513737 - 1545 WP_257175271.1 YjjI family glycine radical enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50377.17 Da        Isoelectric Point: 9.1590

>T256725 WP_279453734.1 NZ_CP103818:508727-510049 [Actinobacillus equuli subsp. haemolyticus]
MVKRLCVLMNGELVGFFERTMSGSHLFRYADEWFLSPNVRPISLSMPLRREVYQGKEVINFFDNLLPDHPQVRARIAARF
QADTQQPFELLAKIGRDATGAITLLEENTKIPNHKVIHATELNEKELHSLLLGYRQNAPLGMLDEAQDFRISIAGAQEKT
ALLWYNERWQLPHGLTPTTHIIKLPIGKIQTPKYQLDLSQSVDNELICLRLCAAFGLPSANVNLLEVGDVRALVVERFDR
KLHSSNQYFLRLPYEDFCQVFGLAPTQKYESDGGVGIRHIMDKLLYSNQISDRTQFMRTQFLFWVLGAIDGHAKNFSIAL
KSQSRYHLSPIYDVISAYPMLGGKGWHQSDLQLAMSLCSTQKGKKWSWQKIRPVHYLSTAKSVGFNQLEMKHIIEEISDT
ALRKLDFVADRLPININEQVRDQIFNGVKKQIGKIKLDNI

Download         Length: 1323 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9295.66 Da        Isoelectric Point: 8.6589

>AT256725 WP_279453733.1 NZ_CP103818:508491-508733 [Actinobacillus equuli subsp. haemolyticus]
MLINDPNSLAVYLRDIRKQQKQSQKMIAQRVGLRQATISTFESQPDKVTIETLFKIAHSLGLEIHLEEKHKNMFNGSDEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References