Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2278865..2279507 Replicon chromosome
Accession NZ_CP103816
Organism Actinobacillus equuli subsp. equuli strain 4026

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR70_RS10540 Protein ID WP_005621659.1
Coordinates 2278865..2279236 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR70_RS10545 Protein ID WP_039198813.1
Coordinates 2279217..2279507 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR70_RS10525 (NYR70_10525) 2275373..2276227 + 855 WP_279477229.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR70_RS10530 (NYR70_10530) 2276271..2276840 - 570 WP_279437970.1 elongation factor P hydroxylase -
NYR70_RS10535 (NYR70_10535) 2276899..2278647 - 1749 WP_279477230.1 protein-disulfide reductase DsbD -
NYR70_RS10540 (NYR70_10540) 2278865..2279236 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR70_RS10545 (NYR70_10545) 2279217..2279507 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR70_RS10550 (NYR70_10550) 2279575..2280537 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR70_RS10555 (NYR70_10555) 2280610..2281107 + 498 WP_278226779.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR70_RS10560 (NYR70_10560) 2281332..2282066 + 735 WP_039198820.1 arginine ABC transporter ATP-binding protein ArtP -
NYR70_RS10565 (NYR70_10565) 2282086..2282805 + 720 WP_279443239.1 transporter substrate-binding domain-containing protein -
NYR70_RS10570 (NYR70_10570) 2282811..2283482 + 672 WP_039198825.1 arginine ABC transporter permease ArtQ -
NYR70_RS10575 (NYR70_10575) 2283482..2284165 + 684 WP_279477231.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256722 WP_005621659.1 NZ_CP103816:2278865-2279236 [Actinobacillus equuli subsp. equuli]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256722 WP_039198813.1 NZ_CP103816:2279217-2279507 [Actinobacillus equuli subsp. equuli]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References