Detailed information of TA system TA256720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higB-toxA/Tad-couple_hipB
• Location: 2350151..2350793
• Replicon: chromosome
• Accession: NZ_CP103815
• Organism: Actinobacillus equuli subsp. haemolyticus strain 4038

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0GF68
• Locus tag: NYR69_RS11020
• Protein ID: WP_005621659.1
• Coordinates: 2350151..2350522 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: NYR69_RS11025
• Protein ID: WP_039198813.1
• Coordinates: 2350503..2350793 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (33-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 14938.10 Da
• Isoelectric Point: 9.5717

>T256720 WP_005621659.1 NZ_CP103815:2350151-2350522 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Nucleotide

• Length: 372 bp

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10821.59 Da
• Isoelectric Point: 8.7275

>AT256720 WP_039198813.1 NZ_CP103815:2350503-2350793 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Nucleotide

• Length: 291 bp

Structures

Toxin

• AlphaFold DB: A0A0A7MI46