256720

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2350151..2350793 Replicon chromosome
Accession NZ_CP103815
Organism Actinobacillus equuli subsp. haemolyticus strain 4038

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR69_RS11020 Protein ID WP_005621659.1
Coordinates 2350151..2350522 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR69_RS11025 Protein ID WP_039198813.1
Coordinates 2350503..2350793 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR69_RS11005 (NYR69_11010) 2346658..2347512 + 855 WP_039198806.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR69_RS11010 (NYR69_11015) 2347556..2348125 - 570 WP_039198809.1 elongation factor P hydroxylase -
NYR69_RS11015 (NYR69_11020) 2348185..2349933 - 1749 WP_279438543.1 protein-disulfide reductase DsbD -
NYR69_RS11020 (NYR69_11025) 2350151..2350522 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR69_RS11025 (NYR69_11030) 2350503..2350793 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR69_RS11030 (NYR69_11035) 2350861..2351823 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR69_RS11035 (NYR69_11040) 2351896..2352393 + 498 WP_279438544.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR69_RS11040 (NYR69_11045) 2352618..2353352 + 735 WP_279438545.1 arginine ABC transporter ATP-binding protein ArtP -
NYR69_RS11045 (NYR69_11050) 2353373..2354092 + 720 WP_279438546.1 transporter substrate-binding domain-containing protein -
NYR69_RS11050 (NYR69_11055) 2354098..2354769 + 672 WP_015674486.1 arginine ABC transporter permease ArtQ -
NYR69_RS11055 (NYR69_11060) 2354769..2355452 + 684 WP_279438547.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256720 WP_005621659.1 NZ_CP103815:2350151-2350522 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256720 WP_039198813.1 NZ_CP103815:2350503-2350793 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References