Detailed information of TA system TA025672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 3601793..3603317
• Replicon: chromosome
• Accession: NC_016078
• Organism: Pelagibacterium halotolerans B2

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: -
• Locus tag: KKY_RS17705
• Protein ID: WP_041528879.1
• Coordinates: 3601793..3602704 (-)
• Length: 304 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: KKY_RS17710
• Protein ID: WP_083824193.1
• Coordinates: 3602694..3603317 (-)
• Length: 208 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KKY_RS17690	3596997..3598745	+	1749	WP_014132755.1	ATP-dependent helicase	-
KKY_RS17695	3598814..3600376	-	1563	WP_041528878.1	hypothetical protein	-
KKY_RS17700	3600366..3601796	-	1431	WP_014132757.1	toll/interleukin-1 receptor domain-containing protein	-
KKY_RS17705	3601793..3602704	-	912	WP_041528879.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KKY_RS17710	3602694..3603317	-	624	WP_083824193.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
KKY_RS19785	3603510..3604730	+	1221	WP_014132760.1	hypothetical protein	-
KKY_RS20185	3604907..3606061	+	1155	WP_014132761.1	reverse transcriptase family protein	-
KKY_RS17725	3606139..3607206	-	1068	WP_041528881.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-257)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (17-56)

Sequences

Toxin

Protein

• Length: 304 a.a.
• Molecular weight: 33508.29 Da
• Isoelectric Point: 4.6558

>T25672 WP_041528879.1 NC_016078:c3602704-3601793 [Pelagibacterium halotolerans B2]
MARKVNNIGASVRARLLARARAENLDFQILLTRYALERLLYRLSISDRRNDFILKGAMLFAVWRDDPFRPTRDLDLLGHG
DPEPAAIAESMRSICSAIVPDDGVIFDIDGIEATPIRDEAEYAGVRVRTSATIAGARVPIQIDVGFGDAITPAALEIEYP
SLLDAPAPMLRAYPPETVIAEKTEAIVSLGVANSRMKDFYDLWMVSQTFAFEGKALTDAVQKTFERRRTPWPEQLPTGLS
DAFASEKDAQWRAFLARDRLAAAPASLIDVADNLRAFLGPVLAREELASWPASGPWMYLEAAE

Nucleotide

• Length: 912 bp

>T25672 NC_016078:c3602704-3601793 [Pelagibacterium halotolerans B2]
ATGGCGCGTAAAGTTAACAATATAGGCGCATCCGTGCGCGCCCGCCTGCTCGCCCGCGCGCGTGCCGAAAATCTGGACTT
CCAGATTTTGCTGACGCGCTACGCCTTGGAACGGCTGCTCTATCGCCTCAGCATCTCGGACCGGCGAAACGATTTCATCT
TGAAGGGCGCGATGCTCTTCGCCGTATGGCGAGACGATCCCTTCCGCCCCACGCGCGACCTTGATCTGCTGGGCCACGGC
GACCCCGAACCCGCTGCAATCGCCGAGAGCATGCGGTCAATCTGTTCAGCCATCGTACCCGACGACGGCGTTATTTTCGA
TATCGATGGAATCGAAGCCACCCCCATCCGCGACGAGGCCGAATACGCCGGCGTACGTGTGAGAACCAGCGCAACAATCG
CTGGCGCGCGCGTTCCCATCCAGATTGATGTCGGCTTCGGTGACGCAATCACACCCGCCGCGCTTGAGATCGAGTACCCC
AGCCTGCTGGACGCCCCGGCACCGATGCTGCGCGCCTACCCGCCTGAAACGGTCATCGCCGAGAAGACTGAAGCGATCGT
CTCGCTCGGTGTTGCCAACAGCCGAATGAAGGATTTTTACGACCTCTGGATGGTTTCGCAGACCTTCGCTTTCGAAGGCA
AGGCTCTCACGGACGCCGTCCAGAAAACCTTCGAGCGACGTCGGACACCCTGGCCCGAGCAATTGCCCACCGGTCTCAGC
GATGCCTTTGCCAGCGAGAAGGACGCCCAGTGGCGAGCATTCCTAGCGCGTGATCGGCTGGCAGCTGCGCCTGCTTCCCT
CATCGACGTCGCCGACAATCTGCGGGCGTTCCTGGGACCGGTATTGGCGCGAGAAGAGCTGGCATCCTGGCCCGCAAGCG
GACCTTGGATGTATCTGGAGGCTGCCGAATGA

Antitoxin

Protein

• Length: 208 a.a.
• Molecular weight: 23045.87 Da
• Isoelectric Point: 10.3275

>AT25672 WP_083824193.1 NC_016078:c3603317-3602694 [Pelagibacterium halotolerans B2]
MSPPSASQRKTACALLSEKGLVRMREFRDAGVGAETVARLVRDGAVERVARGLYQLSGAMPDPQHNFAEASALVPKGVIC
LTSALQYHDMTLQMPSAVWMAIDRTGWKPKVEYPPIRFVRFGTKAMSEGIKRHQIDGVAVPIFEPAKTIVDCFRYRNKIG
LDIALESLREGLRAKRVTPDQLWKFARSARVWTVMRPYVEAMVADGA

Nucleotide

• Length: 624 bp

>AT25672 NC_016078:c3603317-3602694 [Pelagibacterium halotolerans B2]
ATGTCACCACCCTCCGCGTCTCAACGCAAAACCGCTTGCGCCCTCCTGAGCGAGAAGGGCCTTGTCCGCATGCGTGAGTT
TCGCGACGCGGGCGTAGGGGCCGAGACTGTTGCGCGCCTGGTTCGAGACGGCGCAGTCGAACGCGTGGCACGCGGCCTTT
ATCAGCTTTCAGGTGCCATGCCCGATCCGCAGCACAACTTCGCCGAAGCCTCGGCCCTTGTGCCAAAGGGCGTGATCTGC
CTGACCTCCGCGCTGCAGTACCATGACATGACCCTGCAGATGCCATCTGCCGTTTGGATGGCCATCGACCGCACCGGCTG
GAAGCCAAAGGTCGAATATCCCCCGATCCGGTTCGTGCGGTTTGGAACCAAGGCCATGTCTGAAGGCATCAAGCGCCATC
AAATTGACGGGGTCGCTGTCCCGATCTTCGAACCCGCCAAGACGATCGTCGACTGCTTCCGTTACCGCAACAAGATTGGT
CTCGACATCGCCCTTGAAAGCCTGCGCGAGGGACTTCGGGCCAAACGCGTGACGCCAGACCAGCTGTGGAAATTCGCGCG
CTCCGCTCGCGTCTGGACGGTTATGCGCCCCTATGTTGAAGCCATGGTGGCCGATGGCGCGTAA