Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2270080..2270722 Replicon chromosome
Accession NZ_CP103813
Organism Actinobacillus equuli subsp. equuli strain 4130

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR67_RS10530 Protein ID WP_005621659.1
Coordinates 2270080..2270451 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR67_RS10535 Protein ID WP_039198813.1
Coordinates 2270432..2270722 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR67_RS10515 (NYR67_10515) 2266587..2267441 + 855 WP_275217246.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR67_RS10520 (NYR67_10520) 2267485..2268054 - 570 WP_279470882.1 elongation factor P hydroxylase -
NYR67_RS10525 (NYR67_10525) 2268114..2269862 - 1749 WP_279470883.1 protein-disulfide reductase DsbD -
NYR67_RS10530 (NYR67_10530) 2270080..2270451 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR67_RS10535 (NYR67_10535) 2270432..2270722 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR67_RS10540 (NYR67_10540) 2270790..2271752 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR67_RS10545 (NYR67_10545) 2271825..2272322 + 498 WP_039198817.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR67_RS10550 (NYR67_10550) 2272509..2273243 + 735 WP_039198820.1 arginine ABC transporter ATP-binding protein ArtP -
NYR67_RS10555 (NYR67_10555) 2273263..2273982 + 720 WP_279443239.1 transporter substrate-binding domain-containing protein -
NYR67_RS10560 (NYR67_10560) 2273988..2274659 + 672 WP_278226783.1 arginine ABC transporter permease ArtQ -
NYR67_RS10565 (NYR67_10565) 2274659..2275342 + 684 WP_279443240.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256711 WP_005621659.1 NZ_CP103813:2270080-2270451 [Actinobacillus equuli subsp. equuli]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256711 WP_039198813.1 NZ_CP103813:2270432-2270722 [Actinobacillus equuli subsp. equuli]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References