Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2345709..2346351 Replicon chromosome
Accession NZ_CP103812
Organism Actinobacillus equuli subsp. haemolyticus strain 3826

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR84_RS10880 Protein ID WP_005621659.1
Coordinates 2345709..2346080 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR84_RS10885 Protein ID WP_279469954.1
Coordinates 2346061..2346351 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR84_RS10865 (NYR84_10865) 2342216..2343070 + 855 WP_279469952.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR84_RS10870 (NYR84_10870) 2343114..2343683 - 570 WP_115587467.1 elongation factor P hydroxylase -
NYR84_RS10875 (NYR84_10875) 2343743..2345491 - 1749 WP_279469953.1 protein-disulfide reductase DsbD -
NYR84_RS10880 (NYR84_10880) 2345709..2346080 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR84_RS10885 (NYR84_10885) 2346061..2346351 + 291 WP_279469954.1 helix-turn-helix transcriptional regulator Antitoxin
NYR84_RS10890 (NYR84_10890) 2346419..2347381 - 963 WP_279469955.1 calcium/sodium antiporter -
NYR84_RS10895 (NYR84_10895) 2347454..2347951 + 498 WP_039198817.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR84_RS10900 (NYR84_10900) 2348176..2348910 + 735 WP_039198820.1 arginine ABC transporter ATP-binding protein ArtP -
NYR84_RS10905 (NYR84_10905) 2348930..2349649 + 720 WP_279469956.1 transporter substrate-binding domain-containing protein -
NYR84_RS10910 (NYR84_10910) 2349655..2350326 + 672 WP_039198825.1 arginine ABC transporter permease ArtQ -
NYR84_RS10915 (NYR84_10915) 2350326..2351009 + 684 WP_279455017.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256709 WP_005621659.1 NZ_CP103812:2345709-2346080 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10791.57 Da        Isoelectric Point: 8.7275

>AT256709 WP_279469954.1 NZ_CP103812:2346061-2346351 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDEAHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References