Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2360342..2360984 Replicon chromosome
Accession NZ_CP103811
Organism Actinobacillus equuli subsp. equuli strain CCUG2041

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR65_RS11110 Protein ID WP_005621659.1
Coordinates 2360342..2360713 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR65_RS11115 Protein ID WP_039198813.1
Coordinates 2360694..2360984 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR65_RS11095 (NYR65_11095) 2356849..2357703 + 855 WP_039198806.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR65_RS11100 (NYR65_11100) 2357747..2358316 - 570 WP_039198809.1 elongation factor P hydroxylase -
NYR65_RS11105 (NYR65_11105) 2358376..2360124 - 1749 WP_039198811.1 protein-disulfide reductase DsbD -
NYR65_RS11110 (NYR65_11110) 2360342..2360713 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR65_RS11115 (NYR65_11115) 2360694..2360984 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR65_RS11120 (NYR65_11120) 2361052..2362014 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR65_RS11125 (NYR65_11125) 2362087..2362584 + 498 WP_039198817.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR65_RS11130 (NYR65_11130) 2362809..2363543 + 735 WP_039198820.1 arginine ABC transporter ATP-binding protein ArtP -
NYR65_RS11135 (NYR65_11135) 2363563..2364282 + 720 WP_039198822.1 transporter substrate-binding domain-containing protein -
NYR65_RS11140 (NYR65_11140) 2364288..2364959 + 672 WP_039198825.1 arginine ABC transporter permease ArtQ -
NYR65_RS11145 (NYR65_11145) 2364959..2365642 + 684 WP_039198827.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256705 WP_005621659.1 NZ_CP103811:2360342-2360713 [Actinobacillus equuli subsp. equuli]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256705 WP_039198813.1 NZ_CP103811:2360694-2360984 [Actinobacillus equuli subsp. equuli]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References