Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2354333..2354975 Replicon chromosome
Accession NZ_CP103810
Organism Actinobacillus equuli subsp. haemolyticus strain CCUG19799

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR64_RS10975 Protein ID WP_005621659.1
Coordinates 2354333..2354704 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR64_RS10980 Protein ID WP_039198813.1
Coordinates 2354685..2354975 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR64_RS10960 (NYR64_10960) 2350841..2351695 + 855 WP_279437193.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR64_RS10965 (NYR64_10965) 2351739..2352308 - 570 WP_279437970.1 elongation factor P hydroxylase -
NYR64_RS10970 (NYR64_10970) 2352367..2354115 - 1749 WP_279437194.1 protein-disulfide reductase DsbD -
NYR64_RS10975 (NYR64_10975) 2354333..2354704 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR64_RS10980 (NYR64_10980) 2354685..2354975 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR64_RS10985 (NYR64_10985) 2355043..2356005 - 963 WP_039198815.1 calcium/sodium antiporter -
NYR64_RS10990 (NYR64_10990) 2356078..2356575 + 498 WP_039198817.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR64_RS10995 (NYR64_10995) 2356800..2357534 + 735 WP_039198820.1 arginine ABC transporter ATP-binding protein ArtP -
NYR64_RS11000 (NYR64_11000) 2357554..2358273 + 720 WP_279437195.1 transporter substrate-binding domain-containing protein -
NYR64_RS11005 (NYR64_11005) 2358279..2358950 + 672 WP_279437196.1 arginine ABC transporter permease ArtQ -
NYR64_RS11010 (NYR64_11010) 2358950..2359633 + 684 WP_279437198.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256704 WP_005621659.1 NZ_CP103810:2354333-2354704 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256704 WP_039198813.1 NZ_CP103810:2354685-2354975 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References