Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1943890..1945328 Replicon chromosome
Accession NZ_CP103810
Organism Actinobacillus equuli subsp. haemolyticus strain CCUG19799

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYR64_RS08950 Protein ID WP_279436972.1
Coordinates 1944216..1945328 (-) Length 371 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A3N2X7
Locus tag NYR64_RS08945 Protein ID WP_005613259.1
Coordinates 1943890..1944219 (-) Length 110 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR64_RS08930 (NYR64_08930) 1938998..1940278 + 1281 WP_279436970.1 threonine synthase -
NYR64_RS08935 (NYR64_08935) 1940356..1941972 + 1617 WP_279436971.1 pentapeptide repeat-containing protein -
NYR64_RS08940 (NYR64_08940) 1942270..1943595 - 1326 WP_015674100.1 MFS transporter family glucose-6-phosphate receptor UhpC -
NYR64_RS08945 (NYR64_08945) 1943890..1944219 - 330 WP_005613259.1 helix-turn-helix domain-containing protein Antitoxin
NYR64_RS08950 (NYR64_08950) 1944216..1945328 - 1113 WP_279436972.1 HipA domain-containing protein Toxin
NYR64_RS08955 (NYR64_08955) 1945358..1945549 - 192 WP_279436973.1 hypothetical protein -
NYR64_RS08960 (NYR64_08960) 1945989..1946249 + 261 WP_275218489.1 hypothetical protein -
NYR64_RS08965 (NYR64_08965) 1946217..1946897 - 681 WP_279436974.1 DNA methyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(91-293)

Antitoxin

(39-94)


Sequences


Toxin        


Download         Length: 371 a.a.        Molecular weight: 42531.36 Da        Isoelectric Point: 5.7089

>T256701 WP_279436972.1 NZ_CP103810:c1945328-1944216 [Actinobacillus equuli subsp. haemolyticus]
MTALADIIPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAVPEIQSERYFPLNVVQNRQSDFLEYANQ
TGAIVGGATGAGGEAPKLLLKRQDKQIWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTD
LMKLEEGERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYGGNLDHEQTIRNLLNVISASQFSNDFDNRHFVIEWVKR
DLLNIAFGNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGIIRTTTWAKNGDNLQEFAGEYRFDKIADGLSDLIEPD
ILLRELRMLAAQLVDLKSRLTKRGVPKSILDFPAIGFDYLPEKLQRWGLV

Download         Length: 1113 bp


Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12320.45 Da        Isoelectric Point: 10.8292

>AT256701 WP_005613259.1 NZ_CP103810:c1944219-1943890 [Actinobacillus equuli subsp. haemolyticus]
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Download         Length: 330 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A3N2X7

References