Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2108933..2109522 Replicon chromosome
Accession NZ_CP103809
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NYR62_RS09885 Protein ID WP_279468694.1
Coordinates 2109190..2109522 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NYR62_RS09880 Protein ID WP_279475549.1
Coordinates 2108933..2109193 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR62_RS09850 (NYR62_09850) 2104064..2104831 + 768 WP_279475539.1 M48 family metallopeptidase -
NYR62_RS09855 (NYR62_09855) 2105376..2105990 + 615 WP_279457447.1 RNA pyrophosphohydrolase -
NYR62_RS09860 (NYR62_09860) 2105990..2106778 + 789 WP_279475541.1 sulfite exporter TauE/SafE family protein -
NYR62_RS09865 (NYR62_09865) 2106834..2107628 + 795 WP_279475544.1 prolipoprotein diacylglyceryl transferase -
NYR62_RS09870 (NYR62_09870) 2107788..2108018 + 231 WP_279475546.1 hypothetical protein -
NYR62_RS09875 (NYR62_09875) 2108189..2108854 + 666 WP_279475548.1 phosphoglycolate phosphatase -
NYR62_RS09880 (NYR62_09880) 2108933..2109193 + 261 WP_279475549.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NYR62_RS09885 (NYR62_09885) 2109190..2109522 + 333 WP_279468694.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NYR62_RS09890 (NYR62_09890) 2109661..2110689 + 1029 WP_279475550.1 tryptophan--tRNA ligase -
NYR62_RS09895 (NYR62_09895) 2110763..2111209 - 447 WP_279475552.1 macrodomain Ter protein MatP -
NYR62_RS09900 (NYR62_09900) 2111294..2112931 + 1638 WP_279475553.1 AAA family ATPase -
NYR62_RS09905 (NYR62_09905) 2113043..2113573 + 531 WP_279475554.1 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA -
NYR62_RS09910 (NYR62_09910) 2113661..2114191 + 531 WP_279475555.1 type II secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11994.91 Da        Isoelectric Point: 5.8100

>T256700 WP_279468694.1 NZ_CP103809:2109190-2109522 [Actinobacillus genomosp. 1]
MKRGDVYWLDLNPTLGHEQAGCRPVVIVSATAFNLASKLPVVVPITNGGAFAERLGFAVSLQNSGLKTTGIVRCDQPRTV
DIIQRNGKFIEVLPEDLLDEVMARVSVIFE

Download         Length: 333 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9433.89 Da        Isoelectric Point: 4.4982

>AT256700 WP_279475549.1 NZ_CP103809:2108933-2109193 [Actinobacillus genomosp. 1]
MPTVALRQVGGSVAMVIPPAFLQALNLSVGSKVDLSLSEEKLVINPVRPKVKYSLEELLNRSDFESARTEESQIWLDAPQ
VGNEIL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References