256697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 1532181..1532826 Replicon chromosome
Accession NZ_CP103809
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag NYR62_RS06940 Protein ID WP_279456935.1
Coordinates 1532455..1532826 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR62_RS06935 Protein ID WP_279456934.1
Coordinates 1532181..1532474 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR62_RS06905 (NYR62_06905) 1527503..1528186 - 684 WP_279475039.1 arginine ABC transporter permease ArtM -
NYR62_RS06910 (NYR62_06910) 1528186..1528857 - 672 WP_005598470.1 arginine ABC transporter permease ArtQ -
NYR62_RS06915 (NYR62_06915) 1528863..1529582 - 720 WP_279475042.1 transporter substrate-binding domain-containing protein -
NYR62_RS06920 (NYR62_06920) 1529603..1530337 - 735 WP_279456931.1 arginine ABC transporter ATP-binding protein ArtP -
NYR62_RS06925 (NYR62_06925) 1530572..1531069 - 498 WP_279456932.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR62_RS06930 (NYR62_06930) 1531142..1532104 + 963 WP_279468296.1 calcium/sodium antiporter -
NYR62_RS06935 (NYR62_06935) 1532181..1532474 - 294 WP_279456934.1 helix-turn-helix domain-containing protein Antitoxin
NYR62_RS06940 (NYR62_06940) 1532455..1532826 - 372 WP_279456935.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR62_RS06945 (NYR62_06945) 1533028..1534779 + 1752 WP_279475045.1 protein-disulfide reductase DsbD -
NYR62_RS06950 (NYR62_06950) 1534838..1535407 + 570 WP_279475047.1 elongation factor P hydroxylase -
NYR62_RS06955 (NYR62_06955) 1535451..1536305 - 855 WP_279475049.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(31-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 15024.49 Da        Isoelectric Point: 10.2796

>T256697 WP_279456935.1 NZ_CP103809:c1532826-1532455 [Actinobacillus genomosp. 1]
MYEIVFYRDKRGREPVKEFLLRLLKEQQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKNNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10940.92 Da        Isoelectric Point: 10.3120

>AT256697 WP_279456934.1 NZ_CP103809:c1532474-1532181 [Actinobacillus genomosp. 1]
MSPIGSSWTSFEQEIFDELEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKPKVPR

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References