Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2163803..2164392 Replicon chromosome
Accession NZ_CP103808
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NYR61_RS10280 Protein ID WP_279468694.1
Coordinates 2164060..2164392 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NYR61_RS10275 Protein ID WP_279468693.1
Coordinates 2163803..2164063 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR61_RS10245 (NYR61_10245) 2158932..2159699 + 768 WP_279468688.1 M48 family metallopeptidase -
NYR61_RS10250 (NYR61_10250) 2160245..2160862 + 618 WP_279468689.1 RNA pyrophosphohydrolase -
NYR61_RS10255 (NYR61_10255) 2160862..2161650 + 789 WP_279468690.1 sulfite exporter TauE/SafE family protein -
NYR61_RS10260 (NYR61_10260) 2161706..2162500 + 795 WP_279468691.1 prolipoprotein diacylglyceryl transferase -
NYR61_RS10265 (NYR61_10265) 2162659..2162889 + 231 WP_005599594.1 hypothetical protein -
NYR61_RS10270 (NYR61_10270) 2163059..2163724 + 666 WP_279468692.1 phosphoglycolate phosphatase -
NYR61_RS10275 (NYR61_10275) 2163803..2164063 + 261 WP_279468693.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NYR61_RS10280 (NYR61_10280) 2164060..2164392 + 333 WP_279468694.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NYR61_RS10285 (NYR61_10285) 2164531..2165559 + 1029 WP_279468695.1 tryptophan--tRNA ligase -
NYR61_RS10290 (NYR61_10290) 2165632..2166078 - 447 WP_279468696.1 macrodomain Ter protein MatP -
NYR61_RS10295 (NYR61_10295) 2166163..2167800 + 1638 WP_279468697.1 AAA family ATPase -
NYR61_RS10300 (NYR61_10300) 2167912..2168442 + 531 WP_279468699.1 bifunctional 3-hydroxydecanoyl-ACP dehydratase/trans-2-decenoyl-ACP isomerase -
NYR61_RS10305 (NYR61_10305) 2168530..2169060 + 531 WP_279468700.1 type II secretion system protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11994.91 Da        Isoelectric Point: 5.8100

>T256695 WP_279468694.1 NZ_CP103808:2164060-2164392 [Actinobacillus genomosp. 1]
MKRGDVYWLDLNPTLGHEQAGCRPVVIVSATAFNLASKLPVVVPITNGGAFAERLGFAVSLQNSGLKTTGIVRCDQPRTV
DIIQRNGKFIEVLPEDLLDEVMARVSVIFE

Download         Length: 333 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.78 Da        Isoelectric Point: 4.3189

>AT256695 WP_279468693.1 NZ_CP103808:2163803-2164063 [Actinobacillus genomosp. 1]
MPTVALRQVGGSVAMVIPPAFLQALNLSAGSKVDLSLSEEKLVINPVRPKVKYSLEELLNQSDFESARTEESQIWLDAPQ
VGNEIL

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References