Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 1592154..1592799 Replicon chromosome
Accession NZ_CP103808
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag NYR61_RS07350 Protein ID WP_279456935.1
Coordinates 1592428..1592799 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR61_RS07345 Protein ID WP_279468297.1
Coordinates 1592154..1592447 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR61_RS07315 (NYR61_07315) 1587486..1588169 - 684 WP_279456929.1 arginine ABC transporter permease ArtM -
NYR61_RS07320 (NYR61_07320) 1588169..1588840 - 672 WP_005598470.1 arginine ABC transporter permease ArtQ -
NYR61_RS07325 (NYR61_07325) 1588846..1589565 - 720 WP_279468293.1 transporter substrate-binding domain-containing protein -
NYR61_RS07330 (NYR61_07330) 1589586..1590320 - 735 WP_279468294.1 arginine ABC transporter ATP-binding protein ArtP -
NYR61_RS07335 (NYR61_07335) 1590545..1591042 - 498 WP_279468295.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR61_RS07340 (NYR61_07340) 1591115..1592077 + 963 WP_279468296.1 calcium/sodium antiporter -
NYR61_RS07345 (NYR61_07345) 1592154..1592447 - 294 WP_279468297.1 helix-turn-helix domain-containing protein Antitoxin
NYR61_RS07350 (NYR61_07350) 1592428..1592799 - 372 WP_279456935.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR61_RS07355 (NYR61_07355) 1593003..1594751 + 1749 WP_279468298.1 protein-disulfide reductase DsbD -
NYR61_RS07360 (NYR61_07360) 1594811..1595380 + 570 WP_279468299.1 elongation factor P hydroxylase -
NYR61_RS07365 (NYR61_07365) 1595424..1596279 - 856 Protein_1430 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(31-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 15024.49 Da        Isoelectric Point: 10.2796

>T256692 WP_279456935.1 NZ_CP103808:c1592799-1592428 [Actinobacillus genomosp. 1]
MYEIVFYRDKRGREPVKEFLLRLLKEQQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKNNYRIPKREIERAKVRLADLQERIKDEPYWF

Download         Length: 372 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10956.96 Da        Isoelectric Point: 10.3120

>AT256692 WP_279468297.1 NZ_CP103808:c1592447-1592154 [Actinobacillus genomosp. 1]
MSPIGSSWTSFEQEIFDELEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKLKVPR

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References