Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 1853158..1853734 Replicon chromosome
Accession NZ_CP103807
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR60_RS09260 Protein ID WP_279466916.1
Coordinates 1853423..1853734 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR60_RS09255 Protein ID WP_279445789.1
Coordinates 1853158..1853442 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR60_RS09225 (NYR60_09225) 1848519..1849202 - 684 WP_279466905.1 arginine ABC transporter permease ArtM -
NYR60_RS09230 (NYR60_09230) 1849202..1849873 - 672 WP_279466907.1 arginine ABC transporter permease ArtQ -
NYR60_RS09235 (NYR60_09235) 1849879..1850598 - 720 WP_279466909.1 transporter substrate-binding domain-containing protein -
NYR60_RS09240 (NYR60_09240) 1850618..1851352 - 735 WP_279466911.1 arginine ABC transporter ATP-binding protein ArtP -
NYR60_RS09245 (NYR60_09245) 1851560..1852057 - 498 WP_279466913.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR60_RS09250 (NYR60_09250) 1852131..1853093 + 963 WP_279466915.1 calcium/sodium antiporter -
NYR60_RS09255 (NYR60_09255) 1853158..1853442 - 285 WP_279445789.1 helix-turn-helix transcriptional regulator Antitoxin
NYR60_RS09260 (NYR60_09260) 1853423..1853734 - 312 WP_279466916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR60_RS09265 (NYR60_09265) 1853991..1855739 + 1749 WP_279466918.1 protein-disulfide reductase DsbD -
NYR60_RS09270 (NYR60_09270) 1855798..1856367 + 570 WP_279466920.1 elongation factor P hydroxylase -
NYR60_RS09275 (NYR60_09275) 1856411..1857265 - 855 WP_279466922.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12303.29 Da        Isoelectric Point: 10.3989

>T256690 WP_279466916.1 NZ_CP103807:c1853734-1853423 [Actinobacillus genomosp. 2]
VGLLKQSHNDNREKLQKISHHLSILHLHGTRAGENYIKHLEDRIWQIRPMSDCLLLTSIIRGQFVLLHYLAKSHYRIPKR
EIERAKSRLADLQARIKDEPYWF

Download         Length: 312 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10435.21 Da        Isoelectric Point: 10.0168

>AT256690 WP_279445789.1 NZ_CP103807:c1853442-1853158 [Actinobacillus genomosp. 2]
MSPIGSSWHSFEQQVLNPLDIEEQNFRIKLILEIIETRQALGISQRKLESLSGVKQSMIARVEKGSSNPSLATLLKLLVP
LGKTLQIVPLNADK

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References