Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1424062..1424690 Replicon chromosome
Accession NZ_CP103807
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NYR60_RS07145 Protein ID WP_279466397.1
Coordinates 1424062..1424460 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NYR60_RS07150 Protein ID WP_279466398.1
Coordinates 1424460..1424690 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR60_RS07130 (NYR60_07130) 1419273..1420448 - 1176 WP_279466390.1 hypothetical protein -
NYR60_RS07135 (NYR60_07135) 1420451..1421662 - 1212 WP_279466392.1 alpha-2,8-polysialyltransferase family protein -
NYR60_RS07140 (NYR60_07140) 1422042..1423706 + 1665 WP_279466395.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
NYR60_RS07145 (NYR60_07145) 1424062..1424460 - 399 WP_279466397.1 tRNA(fMet)-specific endonuclease VapC Toxin
NYR60_RS07150 (NYR60_07150) 1424460..1424690 - 231 WP_279466398.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NYR60_RS07155 (NYR60_07155) 1424765..1424938 + 174 Protein_1386 addiction module antidote protein, HigA family -
NYR60_RS07160 (NYR60_07160) 1425328..1426692 - 1365 WP_279466400.1 NERD domain-containing protein -
NYR60_RS07165 (NYR60_07165) 1426768..1427046 - 279 WP_279466402.1 hypothetical protein -
NYR60_RS07170 (NYR60_07170) 1427061..1427285 - 225 WP_279466404.1 hypothetical protein -
NYR60_RS07175 (NYR60_07175) 1427275..1428243 - 969 WP_279466405.1 hypothetical protein -
NYR60_RS07180 (NYR60_07180) 1428301..1428459 - 159 WP_279466406.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-53)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15048.30 Da        Isoelectric Point: 6.9788

>T256687 WP_279466397.1 NZ_CP103807:c1424460-1424062 [Actinobacillus genomosp. 2]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKQGEIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLANWV

Download         Length: 399 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8613.65 Da        Isoelectric Point: 4.5358

>AT256687 WP_279466398.1 NZ_CP103807:c1424690-1424460 [Actinobacillus genomosp. 2]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSIRVVGNERILAPINQSWDSFFLSSATVSDDFMTERESSTQAEREEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References