Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-YefM
Location 69273..69940 Replicon chromosome
Accession NZ_CP103807
Organism Actinobacillus genomosp.

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NYR60_RS00355 Protein ID WP_279467052.1
Coordinates 69560..69940 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NYR60_RS00350 Protein ID WP_279467051.1
Coordinates 69273..69560 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR60_RS00335 (NYR60_00335) 64805..65986 + 1182 WP_279467046.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
NYR60_RS00340 (NYR60_00340) 66040..66588 + 549 WP_279467048.1 type IV pilus biogenesis/stability protein PilW -
NYR60_RS00345 (NYR60_00345) 66664..69003 + 2340 WP_279467050.1 Tex family protein -
NYR60_RS00350 (NYR60_00350) 69273..69560 + 288 WP_279467051.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NYR60_RS00355 (NYR60_00355) 69560..69940 + 381 WP_279467052.1 type II toxin-antitoxin system VapC family toxin Toxin
NYR60_RS00360 (NYR60_00360) 70049..71329 - 1281 WP_279467986.1 NAD(P)/FAD-dependent oxidoreductase -
NYR60_RS00365 (NYR60_00365) 71440..71958 - 519 WP_279467053.1 SprT family zinc-dependent metalloprotease -
NYR60_RS00370 (NYR60_00370) 71959..72729 - 771 WP_279467054.1 ribonuclease -
NYR60_RS00375 (NYR60_00375) 72850..74706 - 1857 WP_279467057.1 signal peptide peptidase SppA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14524.13 Da        Isoelectric Point: 8.4870

>T256685 WP_279467052.1 NZ_CP103807:69560-69940 [Actinobacillus genomosp. 2]
MYLLDTNIVSELLKMESGKADAYLSVITLFEIKLGILQLKRKDIQQAKLLQSWFEQKLLPHFENRILPLDTKVMMTCAEF
HIPDKKPLNDSYIAATAKAHRFKIVTRNVKDFKGCGVEVLNPFIDE

Download         Length: 381 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10732.07 Da        Isoelectric Point: 4.7947

>AT256685 WP_279467051.1 NZ_CP103807:69273-69560 [Actinobacillus genomosp. 2]
MAVISSKEFNQRASAVLKIAETEPVYITKWGKVVSVLASYAHYQAQTKSQSLAEAFSSTAPTEILSEEAEQQFEQTLQQV
RQQIKIRVPDLSEWE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References