Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 198361..198951 Replicon plasmid pESI_like
Accession NZ_CP103792
Organism Salmonella enterica subsp. enterica serovar Infantis strain MRS17_00712

Toxin (Protein)


Gene name pemK Uniprot ID A0A241PXU0
Locus tag NYQ90_RS23270 Protein ID WP_023994178.1
Coordinates 198619..198951 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5T3Q5H6
Locus tag NYQ90_RS23265 Protein ID WP_023994179.1
Coordinates 198361..198618 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYQ90_RS23245 (NYQ90_23245) 193861..194885 + 1025 Protein_187 IS630 family transposase -
NYQ90_RS23250 (NYQ90_23250) 194889..195908 - 1020 WP_223155817.1 hypothetical protein -
NYQ90_RS23255 (NYQ90_23255) 196048..196554 - 507 WP_223155815.1 hypothetical protein -
NYQ90_RS23260 (NYQ90_23260) 196665..197750 - 1086 WP_223155813.1 hypothetical protein -
NYQ90_RS23265 (NYQ90_23265) 198361..198618 + 258 WP_023994179.1 hypothetical protein Antitoxin
NYQ90_RS23270 (NYQ90_23270) 198619..198951 + 333 WP_023994178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NYQ90_RS23275 (NYQ90_23275) 199551..200156 + 606 Protein_193 IS481 family transposase -
NYQ90_RS23280 (NYQ90_23280) 200455..202677 - 2223 WP_023994175.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid ant(3'')-Ia / qacE / sul1 / tet(A) fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS / faeC / faeD / faeE / faeF / faeH / faeI 1..278481 278481
- inside IScluster/Tn - - 193849..200156 6307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11787.54 Da        Isoelectric Point: 9.3417

>T256681 WP_023994178.1 NZ_CP103792:198619-198951 [Salmonella enterica subsp. enterica serovar Infantis]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGDFARTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9374.86 Da        Isoelectric Point: 4.4354

>AT256681 WP_023994179.1 NZ_CP103792:198361-198618 [Salmonella enterica subsp. enterica serovar Infantis]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWMDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXU0

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q5H6

References