Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2439122..2439644 Replicon chromosome
Accession NZ_CP103791
Organism Salmonella enterica subsp. enterica serovar Infantis strain MRS17_00712

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NYQ90_RS11805 Protein ID WP_000221343.1
Coordinates 2439122..2439406 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag NYQ90_RS11810 Protein ID WP_000885426.1
Coordinates 2439396..2439644 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYQ90_RS11785 (2435201) 2435201..2436709 - 1509 WP_023993260.1 FAD-dependent oxidoreductase -
NYQ90_RS11790 (2436754) 2436754..2437242 + 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
NYQ90_RS11795 (2437435) 2437435..2438514 + 1080 WP_023993261.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NYQ90_RS11800 (2438562) 2438562..2438951 - 390 WP_023993262.1 RidA family protein -
NYQ90_RS11805 (2439122) 2439122..2439406 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYQ90_RS11810 (2439396) 2439396..2439644 - 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NYQ90_RS11815 (2439796) 2439796..2440011 + 216 WP_023993263.1 phage protein -
NYQ90_RS11820 (2440001) 2440001..2440333 + 333 WP_000253154.1 DUF1493 family protein -
NYQ90_RS11825 (2440613) 2440613..2440807 + 195 Protein_2307 hypothetical protein -
NYQ90_RS11830 (2440806) 2440806..2441252 - 447 Protein_2308 helix-turn-helix domain-containing protein -
NYQ90_RS11835 (2442158) 2442158..2443066 + 909 WP_023994284.1 LysR family transcriptional regulator -
NYQ90_RS11840 (2443240) 2443240..2444220 + 981 WP_023993266.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2433764..2445949 12185


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T256673 WP_000221343.1 NZ_CP103791:c2439406-2439122 [Salmonella enterica subsp. enterica serovar Infantis]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT256673 WP_000885426.1 NZ_CP103791:c2439644-2439396 [Salmonella enterica subsp. enterica serovar Infantis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References