Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1446339..1446959 Replicon chromosome
Accession NZ_CP103791
Organism Salmonella enterica subsp. enterica serovar Infantis strain MRS17_00712

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NYQ90_RS06925 Protein ID WP_001280991.1
Coordinates 1446339..1446557 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NYQ90_RS06930 Protein ID WP_000344807.1
Coordinates 1446585..1446959 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYQ90_RS06885 (1441562) 1441562..1442131 + 570 WP_000779802.1 YbaY family lipoprotein -
NYQ90_RS06890 (1442164) 1442164..1442553 - 390 WP_000961285.1 MGMT family protein -
NYQ90_RS06900 (1442784) 1442784..1444334 - 1551 WP_000213140.1 EAL domain-containing protein -
NYQ90_RS06905 (1444559) 1444559..1444819 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NYQ90_RS06910 (1444825) 1444825..1444965 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NYQ90_RS06915 (1445021) 1445021..1445491 - 471 WP_000136183.1 YlaC family protein -
NYQ90_RS06920 (1445609) 1445609..1446160 - 552 WP_001278793.1 maltose O-acetyltransferase -
NYQ90_RS06925 (1446339) 1446339..1446557 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NYQ90_RS06930 (1446585) 1446585..1446959 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NYQ90_RS06935 (1447455) 1447455..1450604 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NYQ90_RS06940 (1450627) 1450627..1451820 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T256672 WP_001280991.1 NZ_CP103791:c1446557-1446339 [Salmonella enterica subsp. enterica serovar Infantis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT256672 WP_000344807.1 NZ_CP103791:c1446959-1446585 [Salmonella enterica subsp. enterica serovar Infantis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References