Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 204333..205093 Replicon chromosome
Accession NZ_CP103791
Organism Salmonella enterica subsp. enterica serovar Infantis strain MRS17_00712

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag NYQ90_RS00955 Protein ID WP_000533909.1
Coordinates 204608..205093 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NYQ90_RS00950 Protein ID WP_000965886.1
Coordinates 204333..204620 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYQ90_RS00930 (201036) 201036..201464 + 429 Protein_184 IS3 family transposase -
NYQ90_RS00935 (201583) 201583..202233 - 651 WP_023993641.1 GntR family transcriptional regulator -
NYQ90_RS00940 (202318) 202318..203520 + 1203 WP_023201740.1 MFS transporter -
NYQ90_RS00945 (203609) 203609..204167 + 559 Protein_187 cysteine hydrolase -
NYQ90_RS00950 (204333) 204333..204620 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NYQ90_RS00955 (204608) 204608..205093 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
NYQ90_RS00960 (205465) 205465..206004 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
NYQ90_RS00965 (206178) 206178..206390 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NYQ90_RS00970 (206678) 206678..206968 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NYQ90_RS00975 (207407) 207407..208117 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NYQ90_RS00980 (208167) 208167..209141 - 975 WP_023198076.1 glyoxylate/hydroxypyruvate reductase GhrB -
NYQ90_RS00985 (209360) 209360..210022 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T256666 WP_000533909.1 NZ_CP103791:204608-205093 [Salmonella enterica subsp. enterica serovar Infantis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT256666 WP_000965886.1 NZ_CP103791:204333-204620 [Salmonella enterica subsp. enterica serovar Infantis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References