Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 204333..205093 | Replicon | chromosome |
| Accession | NZ_CP103791 | ||
| Organism | Salmonella enterica subsp. enterica serovar Infantis strain MRS17_00712 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | NYQ90_RS00955 | Protein ID | WP_000533909.1 |
| Coordinates | 204608..205093 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | NYQ90_RS00950 | Protein ID | WP_000965886.1 |
| Coordinates | 204333..204620 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NYQ90_RS00930 (201036) | 201036..201464 | + | 429 | Protein_184 | IS3 family transposase | - |
| NYQ90_RS00935 (201583) | 201583..202233 | - | 651 | WP_023993641.1 | GntR family transcriptional regulator | - |
| NYQ90_RS00940 (202318) | 202318..203520 | + | 1203 | WP_023201740.1 | MFS transporter | - |
| NYQ90_RS00945 (203609) | 203609..204167 | + | 559 | Protein_187 | cysteine hydrolase | - |
| NYQ90_RS00950 (204333) | 204333..204620 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| NYQ90_RS00955 (204608) | 204608..205093 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| NYQ90_RS00960 (205465) | 205465..206004 | - | 540 | WP_000047148.1 | copper-binding periplasmic metallochaperone CueP | - |
| NYQ90_RS00965 (206178) | 206178..206390 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| NYQ90_RS00970 (206678) | 206678..206968 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| NYQ90_RS00975 (207407) | 207407..208117 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| NYQ90_RS00980 (208167) | 208167..209141 | - | 975 | WP_023198076.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| NYQ90_RS00985 (209360) | 209360..210022 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T256666 WP_000533909.1 NZ_CP103791:204608-205093 [Salmonella enterica subsp. enterica serovar Infantis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT256666 WP_000965886.1 NZ_CP103791:204333-204620 [Salmonella enterica subsp. enterica serovar Infantis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V2JDX2 |