256665

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1324933..1325849 Replicon chromosome
Accession NZ_CP103784
Organism Bacillus subtilis strain RO-NN-1

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag NYR91_RS06960 Protein ID WP_003244695.1
Coordinates 1325103..1325849 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag NYR91_RS06955 Protein ID WP_003232646.1
Coordinates 1324933..1325103 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR91_RS06920 (NYR91_06920) 1321796..1322125 + 330 WP_014476554.1 XkdW family protein -
NYR91_RS06925 (NYR91_06925) 1322122..1322286 + 165 WP_014476555.1 XkdX family protein -
NYR91_RS06930 (NYR91_06930) 1322330..1323169 + 840 WP_014476556.1 phage-like element PBSX protein XepA -
NYR91_RS06935 (NYR91_06935) 1323222..1323491 + 270 WP_003232655.1 hemolysin XhlA family protein -
NYR91_RS06940 (NYR91_06940) 1323504..1323767 + 264 WP_003232653.1 phage holin -
NYR91_RS06945 (NYR91_06945) 1323780..1324673 + 894 WP_014476557.1 N-acetylmuramoyl-L-alanine amidase -
NYR91_RS06950 (NYR91_06950) 1324710..1324847 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NYR91_RS06955 (NYR91_06955) 1324933..1325103 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NYR91_RS06960 (NYR91_06960) 1325103..1325849 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NYR91_RS06965 (NYR91_06965) 1325959..1326960 - 1002 WP_014476558.1 inorganic phosphate transporter -
NYR91_RS06970 (NYR91_06970) 1326973..1327590 - 618 WP_003218470.1 DUF47 domain-containing protein -
NYR91_RS06975 (NYR91_06975) 1327866..1329182 - 1317 WP_014476559.1 serine/threonine exchanger -
NYR91_RS06980 (NYR91_06980) 1329571..1330521 + 951 WP_014476561.1 ring-cleaving dioxygenase -
NYR91_RS06985 (NYR91_06985) 1330650..1330751 + 102 Protein_1312 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T256665 WP_003244695.1 NZ_CP103784:c1325849-1325103 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT256665 WP_003232646.1 NZ_CP103784:c1325103-1324933 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References