Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 516250..516743 Replicon chromosome
Accession NC_016052
Organism Tetragenococcus halophilus NBRC 12172

Toxin (Protein)


Gene name relE Uniprot ID A0A2H6C3W3
Locus tag TEH_RS02420 Protein ID WP_014123900.1
Coordinates 516477..516743 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2H6CKH8
Locus tag TEH_RS02415 Protein ID WP_014123899.1
Coordinates 516250..516480 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TEH_RS02395 (TEH_04990) 513012..513893 - 882 WP_081497481.1 divalent metal cation transporter -
TEH_RS02400 (TEH_05000) 513896..514255 - 360 WP_014123896.1 divalent metal cation transporter -
TEH_RS02405 (TEH_05010) 514530..515636 - 1107 WP_014123897.1 Ldh family oxidoreductase -
TEH_RS02410 (TEH_05020) 515847..516083 - 237 WP_014123898.1 hypothetical protein -
TEH_RS02415 (TEH_05030) 516250..516480 + 231 WP_014123899.1 hypothetical protein Antitoxin
TEH_RS02420 (TEH_05040) 516477..516743 + 267 WP_014123900.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TEH_RS12910 (TEH_05050) 516956..517138 - 183 WP_014123901.1 putative holin-like toxin -
TEH_RS02425 (TEH_05060) 517789..519090 + 1302 WP_014123902.1 group II intron reverse transcriptase/maturase -
TEH_RS02430 (TEH_05070) 519235..520593 + 1359 WP_014123903.1 transposase -
TEH_RS02435 (TEH_05080) 520709..521356 - 648 WP_014123904.1 pyroglutamyl-peptidase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10597.17 Da        Isoelectric Point: 10.0661

>T25665 WP_014123900.1 NC_016052:516477-516743 [Tetragenococcus halophilus NBRC 12172]
MSYRLVFTSEIQKQFRKMDKYQATLITRWLYQHIDGIDDPRKFGKELTTNRSGQWRYRIGKYRVIVEIEDSQLVVLAVQV
GHEKNVYN

Download         Length: 267 bp

>T25665 NC_016052:516477-516743 [Tetragenococcus halophilus NBRC 12172]
ATGAGCTACCGCTTAGTCTTCACTTCTGAAATACAAAAACAATTTAGAAAAATGGATAAATATCAGGCGACTTTAATTAC
TCGTTGGCTGTATCAGCATATTGATGGAATTGACGACCCTCGCAAATTTGGCAAAGAACTAACTACAAATCGGTCTGGTC
AATGGCGTTATAGAATTGGCAAATATCGTGTTATCGTTGAAATAGAAGATAGCCAATTGGTTGTACTAGCTGTTCAAGTT
GGTCATGAAAAAAATGTTTATAATTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.94 Da        Isoelectric Point: 3.9487

>AT25665 WP_014123899.1 NC_016052:516250-516480 [Tetragenococcus halophilus NBRC 12172]
MAMITVRVSDAEKEWLNYMADFYGISLSDLLKTYSMEQLEDEYDRQTAEIAYKHWLENGKQTVSMDEILSEFGGLE

Download         Length: 231 bp

>AT25665 NC_016052:516250-516480 [Tetragenococcus halophilus NBRC 12172]
ATGGCTATGATTACAGTACGTGTAAGTGACGCGGAAAAAGAATGGTTGAATTATATGGCTGATTTCTACGGAATCTCTTT
GTCTGACCTTTTAAAAACCTATTCGATGGAACAATTAGAAGATGAATATGACCGCCAAACAGCTGAGATTGCATATAAAC
ATTGGCTCGAAAATGGTAAGCAAACAGTATCAATGGATGAAATTCTTTCTGAATTTGGAGGTTTAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2H6C3W3

Antitoxin

Source ID Structure
AlphaFold DB A0A2H6CKH8

References