256644

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1348021..1348937 Replicon chromosome
Accession NZ_CP103783
Organism Bacillus subtilis subsp. subtilis str. 168

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag NYR92_RS07100 Protein ID WP_003244695.1
Coordinates 1348191..1348937 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag NYR92_RS07095 Protein ID WP_003232646.1
Coordinates 1348021..1348191 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR92_RS07060 (1344884) 1344884..1345213 + 330 WP_003232660.1 XkdW family protein -
NYR92_RS07065 (1345210) 1345210..1345374 + 165 WP_003232658.1 XkdX family protein -
NYR92_RS07070 (1345418) 1345418..1346257 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
NYR92_RS07075 (1346310) 1346310..1346579 + 270 WP_003232655.1 hemolysin XhlA family protein -
NYR92_RS07080 (1346592) 1346592..1346855 + 264 WP_003232653.1 phage holin -
NYR92_RS07085 (1346868) 1346868..1347761 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
NYR92_RS07090 (1347798) 1347798..1347935 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NYR92_RS07095 (1348021) 1348021..1348191 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NYR92_RS07100 (1348191) 1348191..1348937 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NYR92_RS07105 (1349047) 1349047..1350048 - 1002 WP_003232642.1 inorganic phosphate transporter -
NYR92_RS07110 (1350061) 1350061..1350678 - 618 WP_003218470.1 DUF47 domain-containing protein -
NYR92_RS07115 (1350954) 1350954..1352270 - 1317 WP_003244819.1 serine/threonine exchanger -
NYR92_RS07120 (1352659) 1352659..1353609 + 951 WP_003245086.1 ring-cleaving dioxygenase -
NYR92_RS07125 (1353710) 1353710..1353856 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1314029..1413453 99424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T256644 WP_003244695.1 NZ_CP103783:c1348937-1348191 [Bacillus subtilis subsp. subtilis str. 168]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT256644 WP_003232646.1 NZ_CP103783:c1348191-1348021 [Bacillus subtilis subsp. subtilis str. 168]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References