256642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1310831..1311748 Replicon chromosome
Accession NZ_CP103782
Organism Bacillus velezensis strain DA4

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NYR48_RS06925 Protein ID WP_259425380.1
Coordinates 1311002..1311748 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NYR48_RS06920 Protein ID WP_003154807.1
Coordinates 1310831..1311001 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR48_RS06880 1306055..1307686 + 1632 WP_259425376.1 pyocin knob domain-containing protein -
NYR48_RS06885 1307699..1308070 + 372 WP_151296633.1 XkdW family protein -
NYR48_RS06890 1308075..1308272 + 198 WP_012117366.1 XkdX family protein -
NYR48_RS06895 1308329..1309090 + 762 WP_259425377.1 phage portal protein -
NYR48_RS06900 1309142..1309405 + 264 WP_003154815.1 hemolysin XhlA family protein -
NYR48_RS06905 1309419..1309682 + 264 WP_259425378.1 phage holin -
NYR48_RS06910 1309696..1310574 + 879 WP_043021264.1 N-acetylmuramoyl-L-alanine amidase -
NYR48_RS06915 1310609..1310734 - 126 WP_259425379.1 hypothetical protein -
NYR48_RS06920 1310831..1311001 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NYR48_RS06925 1311002..1311748 - 747 WP_259425380.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NYR48_RS06930 1311853..1312851 - 999 WP_003154805.1 inorganic phosphate transporter -
NYR48_RS06935 1312864..1313481 - 618 WP_003154804.1 DUF47 domain-containing protein -
NYR48_RS06940 1313767..1315083 - 1317 WP_259425381.1 amino acid permease -
NYR48_RS06945 1315406..1316356 + 951 WP_259425382.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29107.60 Da        Isoelectric Point: 4.7755

>T256642 WP_259425380.1 NZ_CP103782:c1311748-1311002 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLTAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT256642 WP_003154807.1 NZ_CP103782:c1311001-1310831 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References