Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 239859..240501 Replicon chromosome
Accession NZ_CP103777
Organism Bacillus toyonensis strain DC11

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag NYR47_RS01370 Protein ID WP_000635963.1
Coordinates 240151..240501 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag NYR47_RS01365 Protein ID WP_000004570.1
Coordinates 239859..240146 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR47_RS01340 235186..236148 + 963 WP_000961173.1 UV DNA damage repair endonuclease UvsE -
NYR47_RS01345 236141..236713 - 573 WP_000908504.1 rhomboid family intramembrane serine protease -
NYR47_RS01350 236806..237165 + 360 WP_000583421.1 holo-ACP synthase -
NYR47_RS01355 237322..238272 + 951 WP_002059179.1 outer membrane lipoprotein carrier protein LolA -
NYR47_RS01360 238390..239559 + 1170 WP_000390621.1 alanine racemase -
NYR47_RS01365 239859..240146 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
NYR47_RS01370 240151..240501 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
NYR47_RS01375 240570..242738 + 2169 WP_000426215.1 Tex family protein -
NYR47_RS01380 242797..242913 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
NYR47_RS01385 243121..243579 + 459 WP_259416658.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T256639 WP_000635963.1 NZ_CP103777:240151-240501 [Bacillus toyonensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT256639 WP_000004570.1 NZ_CP103777:239859-240146 [Bacillus toyonensis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References