Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4497836..4498596 Replicon chromosome
Accession NZ_CP103771
Organism Salmonella enterica strain S1905

Toxin (Protein)


Gene name tacT Uniprot ID A0A620G002
Locus tag NYS49_RS21905 Protein ID WP_023138210.1
Coordinates 4497836..4498321 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag NYS49_RS21910 Protein ID WP_000965889.1
Coordinates 4498309..4498596 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYS49_RS21875 (4492898) 4492898..4493560 + 663 WP_000747548.1 OmpA family lipoprotein -
NYS49_RS21880 (4493790) 4493790..4494764 + 975 WP_023138208.1 glyoxylate/hydroxypyruvate reductase GhrB -
NYS49_RS21885 (4494814) 4494814..4495524 - 711 WP_023138209.1 DUF3053 domain-containing protein -
NYS49_RS21890 (4495963) 4495963..4496253 + 291 WP_000455790.1 HTH-type transcriptional regulator -
NYS49_RS21895 (4496541) 4496541..4496753 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NYS49_RS21900 (4496926) 4496926..4497465 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
NYS49_RS21905 (4497836) 4497836..4498321 - 486 WP_023138210.1 GNAT family N-acetyltransferase Toxin
NYS49_RS21910 (4498309) 4498309..4498596 - 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
NYS49_RS21915 (4498808) 4498808..4499053 + 246 WP_023138211.1 hypothetical protein -
NYS49_RS21920 (4499110) 4499110..4499691 + 582 WP_187791524.1 hypothetical protein -
NYS49_RS21925 (4499735) 4499735..4500517 - 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -
NYS49_RS21930 (4500514) 4500514..4501536 - 1023 WP_000255946.1 IS21-like element IS100 family transposase -
NYS49_RS21935 (4501934) 4501934..4502271 + 338 Protein_4284 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17643.31 Da        Isoelectric Point: 9.8719

>T256633 WP_023138210.1 NZ_CP103771:c4498321-4497836 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSSHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT256633 WP_000965889.1 NZ_CP103771:c4498596-4498309 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A620G002

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References