Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3793528..3794188 Replicon chromosome
Accession NZ_CP103771
Organism Salmonella enterica strain S1905

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NYS49_RS18440 Protein ID WP_000244756.1
Coordinates 3793528..3793941 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NYS49_RS18445 Protein ID WP_000351186.1
Coordinates 3793922..3794188 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYS49_RS18420 (3789469) 3789469..3791202 - 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -
NYS49_RS18425 (3791208) 3791208..3791921 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NYS49_RS18430 (3791945) 3791945..3792841 - 897 WP_000434303.1 site-specific tyrosine recombinase XerD -
NYS49_RS18435 (3792954) 3792954..3793475 + 522 WP_001055885.1 flavodoxin FldB -
NYS49_RS18440 (3793528) 3793528..3793941 - 414 WP_000244756.1 protein YgfX Toxin
NYS49_RS18445 (3793922) 3793922..3794188 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NYS49_RS18450 (3794438) 3794438..3795418 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
NYS49_RS18455 (3795534) 3795534..3796193 - 660 WP_000250289.1 hemolysin III family protein -
NYS49_RS18460 (3796357) 3796357..3796668 - 312 WP_001182970.1 N(4)-acetylcytidine aminohydrolase -
NYS49_RS18465 (3796827) 3796827..3798260 + 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T256631 WP_000244756.1 NZ_CP103771:c3793941-3793528 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT256631 WP_000351186.1 NZ_CP103771:c3794188-3793922 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References